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High-resolution peripheral quantitative computed tomography: research or clinical practice?
High-resolution peripheral quantitative CT (HR-pQCT) is a low-dose three-dimensional imaging technique, originally developed for in vivo assessment of bone microarchitecture at the distal radius and tibia in osteoporosis. HR-pQCT has the ability to discriminate trabecular and cortical bone compartme...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546468/ https://www.ncbi.nlm.nih.gov/pubmed/37195008 http://dx.doi.org/10.1259/bjr.20221016 |
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author | Gazzotti, Silvia Aparisi Gómez, Maria Pilar Schileo, Enrico Taddei, Fulvia Sangiorgi, Luca Fusaro, Maria Miceli, Marco Guglielmi, Giuseppe Bazzocchi, Alberto |
author_facet | Gazzotti, Silvia Aparisi Gómez, Maria Pilar Schileo, Enrico Taddei, Fulvia Sangiorgi, Luca Fusaro, Maria Miceli, Marco Guglielmi, Giuseppe Bazzocchi, Alberto |
author_sort | Gazzotti, Silvia |
collection | PubMed |
description | High-resolution peripheral quantitative CT (HR-pQCT) is a low-dose three-dimensional imaging technique, originally developed for in vivo assessment of bone microarchitecture at the distal radius and tibia in osteoporosis. HR-pQCT has the ability to discriminate trabecular and cortical bone compartments, providing densitometric and structural parameters. At present, HR-pQCT is mostly used in research settings, despite evidence showing that it may be a valuable tool in osteoporosis and other diseases. This review summarizes the main applications of HR-pQCT and addresses the limitations that currently prevent its integration into routine clinical practice. In particular, the focus is on the use of HR-pQCT in primary and secondary osteoporosis, chronic kidney disease (CKD), endocrine disorders affecting bone, and rare diseases. A section on novel potential applications of HR-pQCT is also present, including assessment of rheumatic diseases, knee osteoarthritis, distal radius/scaphoid fractures, vascular calcifications, effect of medications, and skeletal muscle. The reviewed literature seems to suggest that a more widespread implementation of HR-pQCT in clinical practice would offer notable opportunities. For instance, HR-pQCT can improve the prediction of incident fractures beyond areal bone mineral density provided by dual-energy X-ray absorptiometry. In addition, HR-pQCT may be used for the monitoring of anti-osteoporotic therapy or for the assessment of mineral and bone disorder associated with CKD. Nevertheless, several obstacles currently prevent a broader use of HR-pQCT and would need to be targeted, such as the small number of installed machines worldwide, the uncertain cost-effectiveness, the need for improved reproducibility, and the limited availability of reference normative data sets. |
format | Online Article Text |
id | pubmed-10546468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The British Institute of Radiology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105464682023-10-04 High-resolution peripheral quantitative computed tomography: research or clinical practice? Gazzotti, Silvia Aparisi Gómez, Maria Pilar Schileo, Enrico Taddei, Fulvia Sangiorgi, Luca Fusaro, Maria Miceli, Marco Guglielmi, Giuseppe Bazzocchi, Alberto Br J Radiol Review Article High-resolution peripheral quantitative CT (HR-pQCT) is a low-dose three-dimensional imaging technique, originally developed for in vivo assessment of bone microarchitecture at the distal radius and tibia in osteoporosis. HR-pQCT has the ability to discriminate trabecular and cortical bone compartments, providing densitometric and structural parameters. At present, HR-pQCT is mostly used in research settings, despite evidence showing that it may be a valuable tool in osteoporosis and other diseases. This review summarizes the main applications of HR-pQCT and addresses the limitations that currently prevent its integration into routine clinical practice. In particular, the focus is on the use of HR-pQCT in primary and secondary osteoporosis, chronic kidney disease (CKD), endocrine disorders affecting bone, and rare diseases. A section on novel potential applications of HR-pQCT is also present, including assessment of rheumatic diseases, knee osteoarthritis, distal radius/scaphoid fractures, vascular calcifications, effect of medications, and skeletal muscle. The reviewed literature seems to suggest that a more widespread implementation of HR-pQCT in clinical practice would offer notable opportunities. For instance, HR-pQCT can improve the prediction of incident fractures beyond areal bone mineral density provided by dual-energy X-ray absorptiometry. In addition, HR-pQCT may be used for the monitoring of anti-osteoporotic therapy or for the assessment of mineral and bone disorder associated with CKD. Nevertheless, several obstacles currently prevent a broader use of HR-pQCT and would need to be targeted, such as the small number of installed machines worldwide, the uncertain cost-effectiveness, the need for improved reproducibility, and the limited availability of reference normative data sets. The British Institute of Radiology. 2023-10 2023-05-24 /pmc/articles/PMC10546468/ /pubmed/37195008 http://dx.doi.org/10.1259/bjr.20221016 Text en © 2023 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial reuse, provided the original author and source are credited. |
spellingShingle | Review Article Gazzotti, Silvia Aparisi Gómez, Maria Pilar Schileo, Enrico Taddei, Fulvia Sangiorgi, Luca Fusaro, Maria Miceli, Marco Guglielmi, Giuseppe Bazzocchi, Alberto High-resolution peripheral quantitative computed tomography: research or clinical practice? |
title | High-resolution peripheral quantitative computed tomography: research or clinical practice? |
title_full | High-resolution peripheral quantitative computed tomography: research or clinical practice? |
title_fullStr | High-resolution peripheral quantitative computed tomography: research or clinical practice? |
title_full_unstemmed | High-resolution peripheral quantitative computed tomography: research or clinical practice? |
title_short | High-resolution peripheral quantitative computed tomography: research or clinical practice? |
title_sort | high-resolution peripheral quantitative computed tomography: research or clinical practice? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546468/ https://www.ncbi.nlm.nih.gov/pubmed/37195008 http://dx.doi.org/10.1259/bjr.20221016 |
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