Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brains

BACKGROUND: The genetic underpinnings of late-onset Alzheimer’s disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain largely unknown. Since the brain is composed of heterogenous cell subtypes, it...

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Detalles Bibliográficos
Autores principales: Gamache, Julia, Gingerich, Daniel, Shwab, E. Keats, Barrera, Julio, Garrett, Melanie E., Hume, Cordelia, Crawford, Gregory E., Ashley-Koch, Allison E., Chiba-Falek, Ornit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546724/
https://www.ncbi.nlm.nih.gov/pubmed/37789374
http://dx.doi.org/10.1186/s13578-023-01120-5

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