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QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience
INTRODUCTION: The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution mate...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546968/ https://www.ncbi.nlm.nih.gov/pubmed/37794986 http://dx.doi.org/10.5114/wo.2023.129462 |
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author | Graczyk, Łukasz Bibik, Robert Woźniak, Antoni Jesień-Lewandowicz, Emilia Ciupis, Jacek Szyburski, Michał Bajer, Jakub Chałubińska-Fendler, Justyna Fijuth, Jacek Jońska-Gmyrek, Joanna Gabriela |
author_facet | Graczyk, Łukasz Bibik, Robert Woźniak, Antoni Jesień-Lewandowicz, Emilia Ciupis, Jacek Szyburski, Michał Bajer, Jakub Chałubińska-Fendler, Justyna Fijuth, Jacek Jońska-Gmyrek, Joanna Gabriela |
author_sort | Graczyk, Łukasz |
collection | PubMed |
description | INTRODUCTION: The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution material in terms of the use of hypofractionated QUAD SHOT RT in patients disqualified from surgery. MATERIAL AND METHODS: Between December 2019 and December 2022, nine patients with locally advanced non-melanoma skin cancer were disqualified from surgery and as a result were treated at the Radom Oncology Centre, Poland. Patients were treated with the Radiation Therapy Oncology Group 8502 QUAD SHOT regimen (14.8 Gy/4 fractions, twice-daily treatment with a 6 h interval, on 2 consecutive days). Courses were repeated every 4 weeks 3 times using volumetric modulated arc therapy (VMAT). RESULTS: Grade 2 toxicities were observed in 4 of 9 (44.4%) patients, no grade ≥ 3 acute toxicity was observed. The median age was 79.1 (60–98) years. Irradiated areas were as follows: nose skin (2), cheek (2), eyebrow with eyelid (1), forehead (1), temple (1), sternum (1), and scapula (1). Performance status was as follows: WHO II – 5 patients (55.6%), WHO I – 3 patients, WHO III – one patient. One patient underwent 3 RT courses in 2 areas for a total of 6 treatment courses, 6 patients received 3 courses of treatment, and 2 patients received 2 courses. Additionally, as of 14 March 2023, four patients died of non-malignant causes. CONCLUSIONS: QUAD SHOT schedule with VMAT RT may be an effective palliative treatment method with a good response rate, which positively affects patients’ quality of life in locally advanced non-melanoma skin cancer patients disqualified from surgery. |
format | Online Article Text |
id | pubmed-10546968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-105469682023-10-04 QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience Graczyk, Łukasz Bibik, Robert Woźniak, Antoni Jesień-Lewandowicz, Emilia Ciupis, Jacek Szyburski, Michał Bajer, Jakub Chałubińska-Fendler, Justyna Fijuth, Jacek Jońska-Gmyrek, Joanna Gabriela Contemp Oncol (Pozn) Original Paper INTRODUCTION: The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution material in terms of the use of hypofractionated QUAD SHOT RT in patients disqualified from surgery. MATERIAL AND METHODS: Between December 2019 and December 2022, nine patients with locally advanced non-melanoma skin cancer were disqualified from surgery and as a result were treated at the Radom Oncology Centre, Poland. Patients were treated with the Radiation Therapy Oncology Group 8502 QUAD SHOT regimen (14.8 Gy/4 fractions, twice-daily treatment with a 6 h interval, on 2 consecutive days). Courses were repeated every 4 weeks 3 times using volumetric modulated arc therapy (VMAT). RESULTS: Grade 2 toxicities were observed in 4 of 9 (44.4%) patients, no grade ≥ 3 acute toxicity was observed. The median age was 79.1 (60–98) years. Irradiated areas were as follows: nose skin (2), cheek (2), eyebrow with eyelid (1), forehead (1), temple (1), sternum (1), and scapula (1). Performance status was as follows: WHO II – 5 patients (55.6%), WHO I – 3 patients, WHO III – one patient. One patient underwent 3 RT courses in 2 areas for a total of 6 treatment courses, 6 patients received 3 courses of treatment, and 2 patients received 2 courses. Additionally, as of 14 March 2023, four patients died of non-malignant causes. CONCLUSIONS: QUAD SHOT schedule with VMAT RT may be an effective palliative treatment method with a good response rate, which positively affects patients’ quality of life in locally advanced non-melanoma skin cancer patients disqualified from surgery. Termedia Publishing House 2023-07-21 2023 /pmc/articles/PMC10546968/ /pubmed/37794986 http://dx.doi.org/10.5114/wo.2023.129462 Text en Copyright © 2023 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Graczyk, Łukasz Bibik, Robert Woźniak, Antoni Jesień-Lewandowicz, Emilia Ciupis, Jacek Szyburski, Michał Bajer, Jakub Chałubińska-Fendler, Justyna Fijuth, Jacek Jońska-Gmyrek, Joanna Gabriela QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience |
title | QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience |
title_full | QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience |
title_fullStr | QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience |
title_full_unstemmed | QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience |
title_short | QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience |
title_sort | quad shot – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. a single-institution experience |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546968/ https://www.ncbi.nlm.nih.gov/pubmed/37794986 http://dx.doi.org/10.5114/wo.2023.129462 |
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