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Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021
Through the Chinese National Immunization Adverse Event Surveillance System (CNAEFIS), we collected reports of Adverse Event Following Immunization (AEFI) deaths in Shenyang from 2009 to 2021 with the aim of analyzing AEFI-related deaths and assessing the safety of vaccination. From 2009 to 2021, a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547072/ https://www.ncbi.nlm.nih.gov/pubmed/37782096 http://dx.doi.org/10.1080/21645515.2023.2263225 |
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author | Gao, Dongmei Dong, Guihua Zhu, Lijun Jia, Nina Sun, Baijun |
author_facet | Gao, Dongmei Dong, Guihua Zhu, Lijun Jia, Nina Sun, Baijun |
author_sort | Gao, Dongmei |
collection | PubMed |
description | Through the Chinese National Immunization Adverse Event Surveillance System (CNAEFIS), we collected reports of Adverse Event Following Immunization (AEFI) deaths in Shenyang from 2009 to 2021 with the aim of analyzing AEFI-related deaths and assessing the safety of vaccination. From 2009 to 2021, a total of 12 AEFI-related deaths were reported in Shenyang City, and autopsies were performed in 6 deaths. According to the assessment of the Expert Committee on Investigation and Diagnosis of AEFI 3 (25.0%) deaths were classified as severe vaccine reactions, 9 (75.0%) deaths were classified as coincidental events, and there were no immunization errors or psychological reactions. The overall estimated AEFI-related mortality rate was 0.12 per 100,000 vaccination doses. Spearman’s rank correlation analysis showed no correlation between AEFI, severe vaccine reactions, and suspected vaccination-related deaths. Coincidental events are the most common type of death following vaccination, meaning that the risk of death following immunization is low, and ongoing AEFI surveillance and scientific causality assessment are essential to ensure the vaccine confidence. Detailed pre-vaccination health status questioning is also key to avoiding and reducing adverse events. |
format | Online Article Text |
id | pubmed-10547072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-105470722023-10-04 Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 Gao, Dongmei Dong, Guihua Zhu, Lijun Jia, Nina Sun, Baijun Hum Vaccin Immunother Brief Report Through the Chinese National Immunization Adverse Event Surveillance System (CNAEFIS), we collected reports of Adverse Event Following Immunization (AEFI) deaths in Shenyang from 2009 to 2021 with the aim of analyzing AEFI-related deaths and assessing the safety of vaccination. From 2009 to 2021, a total of 12 AEFI-related deaths were reported in Shenyang City, and autopsies were performed in 6 deaths. According to the assessment of the Expert Committee on Investigation and Diagnosis of AEFI 3 (25.0%) deaths were classified as severe vaccine reactions, 9 (75.0%) deaths were classified as coincidental events, and there were no immunization errors or psychological reactions. The overall estimated AEFI-related mortality rate was 0.12 per 100,000 vaccination doses. Spearman’s rank correlation analysis showed no correlation between AEFI, severe vaccine reactions, and suspected vaccination-related deaths. Coincidental events are the most common type of death following vaccination, meaning that the risk of death following immunization is low, and ongoing AEFI surveillance and scientific causality assessment are essential to ensure the vaccine confidence. Detailed pre-vaccination health status questioning is also key to avoiding and reducing adverse events. Taylor & Francis 2023-10-02 /pmc/articles/PMC10547072/ /pubmed/37782096 http://dx.doi.org/10.1080/21645515.2023.2263225 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Brief Report Gao, Dongmei Dong, Guihua Zhu, Lijun Jia, Nina Sun, Baijun Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 |
title | Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 |
title_full | Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 |
title_fullStr | Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 |
title_full_unstemmed | Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 |
title_short | Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021 |
title_sort | analysis of death cases in shenyang city, china, for immunization adverse event surveillance, 2009-2021 |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547072/ https://www.ncbi.nlm.nih.gov/pubmed/37782096 http://dx.doi.org/10.1080/21645515.2023.2263225 |
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