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Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease

BACKGROUND: Dietary magnesium and serum magnesium play an important part in cardiovascular disease (CVD). However, the association between magnesium depletion score (MDS) and CVD development and prognosis remains unclear. This analysis examines the cross‐sectional relationship between MDS and CVD, a...

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Autores principales: Ye, Liu, Zhang, Cheng, Duan, Qin, Shao, Yue, Zhou, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547298/
https://www.ncbi.nlm.nih.gov/pubmed/37681518
http://dx.doi.org/10.1161/JAHA.123.030077
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author Ye, Liu
Zhang, Cheng
Duan, Qin
Shao, Yue
Zhou, Jianzhong
author_facet Ye, Liu
Zhang, Cheng
Duan, Qin
Shao, Yue
Zhou, Jianzhong
author_sort Ye, Liu
collection PubMed
description BACKGROUND: Dietary magnesium and serum magnesium play an important part in cardiovascular disease (CVD). However, the association between magnesium depletion score (MDS) and CVD development and prognosis remains unclear. This analysis examines the cross‐sectional relationship between MDS and CVD, and the longitudinal association between MDS and all‐cause and CVD mortality in individuals with CVD. METHODS AND RESULTS: In all, 42 711 individuals were selected from the National Health and Nutrition Examination Survey, including 5015 subjects with CVD. The association between MDS and total and individual CVDs was examined using the survey‐weighted multiple logistic regression analysis. Among 5011 patients with CVD, 2285 and 927 participants were recorded with all‐cause and CVD deaths, respectively. We applied survey‐weighted Cox proportional hazards regression analyses to investigate the impact of MDS on the mortality of individuals with CVD. The CVD group had higher MDS levels than the non‐CVD groups. After controlling all confounding factors, individuals with MDS of 2 and ≥3 had higher odds of total CVD and specific CVD than those with MDS of 0. Besides, each 1‐unit increase in MDS was strongly related to the risk of total CVD and specific CVD. The relationship between MDS and total CVD was stable and significant in all subgroups. The fully adjusted Cox regression model indicated that high MDS, irrespective of MDS as a categorical or continuous variable, was significantly associated with an elevated risk of all‐cause and CVD deaths. CONCLUSIONS: MDS is a vital risk factor for the prevalence and mortality of individuals with CVD.
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spelling pubmed-105472982023-10-04 Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease Ye, Liu Zhang, Cheng Duan, Qin Shao, Yue Zhou, Jianzhong J Am Heart Assoc Original Research BACKGROUND: Dietary magnesium and serum magnesium play an important part in cardiovascular disease (CVD). However, the association between magnesium depletion score (MDS) and CVD development and prognosis remains unclear. This analysis examines the cross‐sectional relationship between MDS and CVD, and the longitudinal association between MDS and all‐cause and CVD mortality in individuals with CVD. METHODS AND RESULTS: In all, 42 711 individuals were selected from the National Health and Nutrition Examination Survey, including 5015 subjects with CVD. The association between MDS and total and individual CVDs was examined using the survey‐weighted multiple logistic regression analysis. Among 5011 patients with CVD, 2285 and 927 participants were recorded with all‐cause and CVD deaths, respectively. We applied survey‐weighted Cox proportional hazards regression analyses to investigate the impact of MDS on the mortality of individuals with CVD. The CVD group had higher MDS levels than the non‐CVD groups. After controlling all confounding factors, individuals with MDS of 2 and ≥3 had higher odds of total CVD and specific CVD than those with MDS of 0. Besides, each 1‐unit increase in MDS was strongly related to the risk of total CVD and specific CVD. The relationship between MDS and total CVD was stable and significant in all subgroups. The fully adjusted Cox regression model indicated that high MDS, irrespective of MDS as a categorical or continuous variable, was significantly associated with an elevated risk of all‐cause and CVD deaths. CONCLUSIONS: MDS is a vital risk factor for the prevalence and mortality of individuals with CVD. John Wiley and Sons Inc. 2023-09-08 /pmc/articles/PMC10547298/ /pubmed/37681518 http://dx.doi.org/10.1161/JAHA.123.030077 Text en © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Ye, Liu
Zhang, Cheng
Duan, Qin
Shao, Yue
Zhou, Jianzhong
Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease
title Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease
title_full Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease
title_fullStr Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease
title_full_unstemmed Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease
title_short Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease
title_sort association of magnesium depletion score with cardiovascular disease and its association with longitudinal mortality in patients with cardiovascular disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547298/
https://www.ncbi.nlm.nih.gov/pubmed/37681518
http://dx.doi.org/10.1161/JAHA.123.030077
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