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Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells

A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed in cancer cells results in the loss of epigenetic repression of TEs. The aging process is similarly characterized by changes to the methylom...

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Detalles Bibliográficos
Autores principales:	Senapati, Parijat, Miyano, Masaru, Sayaman, Rosalyn W., Basam, Mudaser, Leung, Amy, LaBarge, Mark A., Schones, Dustin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547379/ https://www.ncbi.nlm.nih.gov/pubmed/37463750 http://dx.doi.org/10.1101/gr.277511.122

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