Cargando…

Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation

BACKGROUND: The role of host immune system in carcinogenesis and response to treatment is increasingly studied, including predictive potential of circulating neutrophils and lymphocytes. The objective of the study was to evaluate the prognostic value of pre- and post-treatment neutrophil-to-lymphocy...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaźmierska, Joanna, Bajon, Tomasz, Winiecki, Tomasz, Borowczak, Dominika, Bandurska-Luque, Anna, Jankowska, Malgorzata, Żmijewska-Tomczak, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547399/
https://www.ncbi.nlm.nih.gov/pubmed/37795402
http://dx.doi.org/10.5603/RPOR.a2023.0042
_version_ 1785115051278991360
author Kaźmierska, Joanna
Bajon, Tomasz
Winiecki, Tomasz
Borowczak, Dominika
Bandurska-Luque, Anna
Jankowska, Malgorzata
Żmijewska-Tomczak, Małgorzata
author_facet Kaźmierska, Joanna
Bajon, Tomasz
Winiecki, Tomasz
Borowczak, Dominika
Bandurska-Luque, Anna
Jankowska, Malgorzata
Żmijewska-Tomczak, Małgorzata
author_sort Kaźmierska, Joanna
collection PubMed
description BACKGROUND: The role of host immune system in carcinogenesis and response to treatment is increasingly studied, including predictive potential of circulating neutrophils and lymphocytes. The objective of the study was to evaluate the prognostic value of pre- and post-treatment neutrophil-to-lymphocyte (NLR) for treatment outcome in patients diagnosed with squamous cell carcinoma of head and neck (HNSCC) treated with definitive chemoradiation. MATERIALS AND METHODS: Electronic medical records of patients were evaluated and NLR was calculated. Cox regression was used to assess the impact of selected variables on overall survival (OS), disease specific survival (DSS), progression free survival (PFS) and distant failure free survival (DFFS). Logistic regression was used to estimate odds ratios of complete response with NLR. RESULTS: 317 patients’ records were included in the study. Increases in both pre-and post-NLR were associated with decreased OS in univariable analysis [hazard ratio (HR): 2.26 (1.25–4.07), p = 0.0068 and HR: 1.57 (1.03–2.37), p = 0.035 respectively). Post-NLR remained significant for OS in multivariable analysis [HR: 1.93 (1.22–3.1), p = 0.005] as well as for unfavorable DSS [HR: 2.31 (1.22–4.4), p = 0.01]. Pre-treatment NLR and nodal status correlated with shorter DFFS in multivariable analysis [HR 4.1 (1.14–14), p = 0.03 and HR 5.3: (1.62–18), p = 0.0062, respectively]. Strong correlation of increased both pre- and post-NLR with probability of clinical tumor response (CR) was found [odds ratio (OR): 0.23 (0.08–0.6), p = 0.003, and OR: 0.39 (0.2–0.8), p = 0.01 respectively]. CONCLUSION: NLR evaluated before and post treatment was a strong predictor of unfavorable treatment outcome and can be used for risk evaluation and clinical decision about treatment and post-treatment surveillance.
format Online
Article
Text
id pubmed-10547399
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Via Medica
record_format MEDLINE/PubMed
spelling pubmed-105473992023-10-04 Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation Kaźmierska, Joanna Bajon, Tomasz Winiecki, Tomasz Borowczak, Dominika Bandurska-Luque, Anna Jankowska, Malgorzata Żmijewska-Tomczak, Małgorzata Rep Pract Oncol Radiother Research Paper BACKGROUND: The role of host immune system in carcinogenesis and response to treatment is increasingly studied, including predictive potential of circulating neutrophils and lymphocytes. The objective of the study was to evaluate the prognostic value of pre- and post-treatment neutrophil-to-lymphocyte (NLR) for treatment outcome in patients diagnosed with squamous cell carcinoma of head and neck (HNSCC) treated with definitive chemoradiation. MATERIALS AND METHODS: Electronic medical records of patients were evaluated and NLR was calculated. Cox regression was used to assess the impact of selected variables on overall survival (OS), disease specific survival (DSS), progression free survival (PFS) and distant failure free survival (DFFS). Logistic regression was used to estimate odds ratios of complete response with NLR. RESULTS: 317 patients’ records were included in the study. Increases in both pre-and post-NLR were associated with decreased OS in univariable analysis [hazard ratio (HR): 2.26 (1.25–4.07), p = 0.0068 and HR: 1.57 (1.03–2.37), p = 0.035 respectively). Post-NLR remained significant for OS in multivariable analysis [HR: 1.93 (1.22–3.1), p = 0.005] as well as for unfavorable DSS [HR: 2.31 (1.22–4.4), p = 0.01]. Pre-treatment NLR and nodal status correlated with shorter DFFS in multivariable analysis [HR 4.1 (1.14–14), p = 0.03 and HR 5.3: (1.62–18), p = 0.0062, respectively]. Strong correlation of increased both pre- and post-NLR with probability of clinical tumor response (CR) was found [odds ratio (OR): 0.23 (0.08–0.6), p = 0.003, and OR: 0.39 (0.2–0.8), p = 0.01 respectively]. CONCLUSION: NLR evaluated before and post treatment was a strong predictor of unfavorable treatment outcome and can be used for risk evaluation and clinical decision about treatment and post-treatment surveillance. Via Medica 2023-07-25 /pmc/articles/PMC10547399/ /pubmed/37795402 http://dx.doi.org/10.5603/RPOR.a2023.0042 Text en © 2023 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
spellingShingle Research Paper
Kaźmierska, Joanna
Bajon, Tomasz
Winiecki, Tomasz
Borowczak, Dominika
Bandurska-Luque, Anna
Jankowska, Malgorzata
Żmijewska-Tomczak, Małgorzata
Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
title Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
title_full Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
title_fullStr Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
title_full_unstemmed Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
title_short Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
title_sort significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547399/
https://www.ncbi.nlm.nih.gov/pubmed/37795402
http://dx.doi.org/10.5603/RPOR.a2023.0042
work_keys_str_mv AT kazmierskajoanna significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation
AT bajontomasz significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation
AT winieckitomasz significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation
AT borowczakdominika significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation
AT bandurskaluqueanna significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation
AT jankowskamalgorzata significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation
AT zmijewskatomczakmałgorzata significanceofneutrophiltolymphocyteratioasapredictorofoutcomeinheadandneckcancertreatedwithdefinitivechemoradiation