Cargando…
Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT
BACKGROUND: The knowledge of the risks induced by radiation with hypofractionation regimens has only recently been estimated together with its implementation as a management standard. However, the dose to other risk organs with intensity-modulated radiation therapy (IMRT) or volumetric modulated arc...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Via Medica
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547416/ https://www.ncbi.nlm.nih.gov/pubmed/37795223 http://dx.doi.org/10.5603/RPOR.a2023.0053 |
_version_ | 1785115055253094400 |
---|---|
author | Mondragon, Lorena Lio Lopez, Hidralba Pérez Diaz, Adolfo Fernández Lio, Iván Avilés Guzman, Alejandro Olmos |
author_facet | Mondragon, Lorena Lio Lopez, Hidralba Pérez Diaz, Adolfo Fernández Lio, Iván Avilés Guzman, Alejandro Olmos |
author_sort | Mondragon, Lorena Lio |
collection | PubMed |
description | BACKGROUND: The knowledge of the risks induced by radiation with hypofractionation regimens has only recently been estimated together with its implementation as a management standard. However, the dose to other risk organs with intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) is not clear, that is why this is only a reference study of radiation doses to organs at risk in hypofractionation in our center. MATERIALS AND METHODS: We completed a retrospective and observational analysis of 1398 patients treated with adjuvant hypofractionated radiotherapy from 2015 to 2018, using the clinical records and dose-volume histogram of patients treated with moderate hypofractionated adjuvant radiotherapy. To analyze the institutional experience on the dosimetry of the esophagus and liver as risk organs in the use of moderate adjuvant hypofractionated radiotherapy in breast cancer. RESULTS: The dosimetry of the esophagus was 3271 cGy DMax, 177 cGy DMed, 68 cGy D50%, 500 cGy DcMAX with 3D RT and 4124 cGy DMax, 1242 cGy DMed, 934.50 cGy D50%, 3213 cGy DcMAX with IMRT/VMAT and the dosimetry for the liver was for right breast cancer 466 cGy DMed, 102 cGy D50% and 8% V20, for left breast cancer 22 cGy DMed, 6.10 cGy D50% and 0.3% V20. CONCLUSION: The statistically significant differences in irradiation show the lack of consensus on the optimal restrictions in hypofractionation regimens to reduce clinical sequela; consequently, the variability in the specification of each radiation oncologist is observed; standardization in our center can lead to improvement in the quality of treatments. |
format | Online Article Text |
id | pubmed-10547416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Via Medica |
record_format | MEDLINE/PubMed |
spelling | pubmed-105474162023-10-04 Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT Mondragon, Lorena Lio Lopez, Hidralba Pérez Diaz, Adolfo Fernández Lio, Iván Avilés Guzman, Alejandro Olmos Rep Pract Oncol Radiother Research Paper BACKGROUND: The knowledge of the risks induced by radiation with hypofractionation regimens has only recently been estimated together with its implementation as a management standard. However, the dose to other risk organs with intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) is not clear, that is why this is only a reference study of radiation doses to organs at risk in hypofractionation in our center. MATERIALS AND METHODS: We completed a retrospective and observational analysis of 1398 patients treated with adjuvant hypofractionated radiotherapy from 2015 to 2018, using the clinical records and dose-volume histogram of patients treated with moderate hypofractionated adjuvant radiotherapy. To analyze the institutional experience on the dosimetry of the esophagus and liver as risk organs in the use of moderate adjuvant hypofractionated radiotherapy in breast cancer. RESULTS: The dosimetry of the esophagus was 3271 cGy DMax, 177 cGy DMed, 68 cGy D50%, 500 cGy DcMAX with 3D RT and 4124 cGy DMax, 1242 cGy DMed, 934.50 cGy D50%, 3213 cGy DcMAX with IMRT/VMAT and the dosimetry for the liver was for right breast cancer 466 cGy DMed, 102 cGy D50% and 8% V20, for left breast cancer 22 cGy DMed, 6.10 cGy D50% and 0.3% V20. CONCLUSION: The statistically significant differences in irradiation show the lack of consensus on the optimal restrictions in hypofractionation regimens to reduce clinical sequela; consequently, the variability in the specification of each radiation oncologist is observed; standardization in our center can lead to improvement in the quality of treatments. Via Medica 2023-08-28 /pmc/articles/PMC10547416/ /pubmed/37795223 http://dx.doi.org/10.5603/RPOR.a2023.0053 Text en © 2023 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially |
spellingShingle | Research Paper Mondragon, Lorena Lio Lopez, Hidralba Pérez Diaz, Adolfo Fernández Lio, Iván Avilés Guzman, Alejandro Olmos Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT |
title | Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT |
title_full | Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT |
title_fullStr | Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT |
title_full_unstemmed | Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT |
title_short | Beyond the heart in hypofractionated radiotherapy and in the transition from 3D to IMRT/VMAT |
title_sort | beyond the heart in hypofractionated radiotherapy and in the transition from 3d to imrt/vmat |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547416/ https://www.ncbi.nlm.nih.gov/pubmed/37795223 http://dx.doi.org/10.5603/RPOR.a2023.0053 |
work_keys_str_mv | AT mondragonlorenalio beyondtheheartinhypofractionatedradiotherapyandinthetransitionfrom3dtoimrtvmat AT lopezhidralbaperez beyondtheheartinhypofractionatedradiotherapyandinthetransitionfrom3dtoimrtvmat AT diazadolfofernandez beyondtheheartinhypofractionatedradiotherapyandinthetransitionfrom3dtoimrtvmat AT lioivanaviles beyondtheheartinhypofractionatedradiotherapyandinthetransitionfrom3dtoimrtvmat AT guzmanalejandroolmos beyondtheheartinhypofractionatedradiotherapyandinthetransitionfrom3dtoimrtvmat |