JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain

Progressive multifocal leukoencephalopathy (PML) is a severe neurological condition caused by reactivation of JC polyomavirus (JCPyV) in immunosuppression. Asymptomatic JCPyV persists in peripheral tissues. Upon reactivation, neurotropic rearrangements may emerge, and the virus gains access to the b...

Descripción completa

Detalles Bibliográficos
Autores principales: Honkimaa, Anni, Suppula, Joni, Tynninen, Olli, Saarela, Mika, Liimatainen, Hanna, Laine, Pia, Auvinen, Petri, Auvinen, Eeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547454/
https://www.ncbi.nlm.nih.gov/pubmed/36988117
http://dx.doi.org/10.1093/infdis/jiad083
_version_ 1785115063280992256
author Honkimaa, Anni
Suppula, Joni
Tynninen, Olli
Saarela, Mika
Liimatainen, Hanna
Laine, Pia
Auvinen, Petri
Auvinen, Eeva
author_facet Honkimaa, Anni
Suppula, Joni
Tynninen, Olli
Saarela, Mika
Liimatainen, Hanna
Laine, Pia
Auvinen, Petri
Auvinen, Eeva
author_sort Honkimaa, Anni
collection PubMed
description Progressive multifocal leukoencephalopathy (PML) is a severe neurological condition caused by reactivation of JC polyomavirus (JCPyV) in immunosuppression. Asymptomatic JCPyV persists in peripheral tissues. Upon reactivation, neurotropic rearrangements may emerge, and the virus gains access to the brain. To assess the mechanisms of PML pathogenesis, brain tissue material from PML patients was collected for small RNA sequencing. Upregulation of 8 microRNAs (miRNAs) in PML brain was validated using quantitative microRNA polymerase chain reaction (PCR). Bioinformatics tools were utilized to identify major associations of the upregulated miRNAs: neuroinflammation and blood-brain barrier disruption. The results indicate involvement of human miRNA regulation in PML pathogenesis.
format Online
Article
Text
id pubmed-10547454
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-105474542023-10-04 JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain Honkimaa, Anni Suppula, Joni Tynninen, Olli Saarela, Mika Liimatainen, Hanna Laine, Pia Auvinen, Petri Auvinen, Eeva J Infect Dis Brief Report Progressive multifocal leukoencephalopathy (PML) is a severe neurological condition caused by reactivation of JC polyomavirus (JCPyV) in immunosuppression. Asymptomatic JCPyV persists in peripheral tissues. Upon reactivation, neurotropic rearrangements may emerge, and the virus gains access to the brain. To assess the mechanisms of PML pathogenesis, brain tissue material from PML patients was collected for small RNA sequencing. Upregulation of 8 microRNAs (miRNAs) in PML brain was validated using quantitative microRNA polymerase chain reaction (PCR). Bioinformatics tools were utilized to identify major associations of the upregulated miRNAs: neuroinflammation and blood-brain barrier disruption. The results indicate involvement of human miRNA regulation in PML pathogenesis. Oxford University Press 2023-03-29 /pmc/articles/PMC10547454/ /pubmed/36988117 http://dx.doi.org/10.1093/infdis/jiad083 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Honkimaa, Anni
Suppula, Joni
Tynninen, Olli
Saarela, Mika
Liimatainen, Hanna
Laine, Pia
Auvinen, Petri
Auvinen, Eeva
JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain
title JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain
title_full JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain
title_fullStr JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain
title_full_unstemmed JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain
title_short JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain
title_sort jc polyomavirus modifies the expression of human micrornas in progressive multifocal leukoencephalopathy brain
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547454/
https://www.ncbi.nlm.nih.gov/pubmed/36988117
http://dx.doi.org/10.1093/infdis/jiad083
work_keys_str_mv AT honkimaaanni jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT suppulajoni jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT tynninenolli jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT saarelamika jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT liimatainenhanna jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT lainepia jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT auvinenpetri jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain
AT auvineneeva jcpolyomavirusmodifiestheexpressionofhumanmicrornasinprogressivemultifocalleukoencephalopathybrain

Ejemplares similares