Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort

BACKGROUND: Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor. METHODS: In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-...

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Autores principales: El-Heneidy, Asmaa, Grimwood, Keith, Lambert, Stephen B, Ware, Robert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547457/
https://www.ncbi.nlm.nih.gov/pubmed/37014728
http://dx.doi.org/10.1093/infdis/jiad094
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author El-Heneidy, Asmaa
Grimwood, Keith
Lambert, Stephen B
Ware, Robert S
author_facet El-Heneidy, Asmaa
Grimwood, Keith
Lambert, Stephen B
Ware, Robert S
author_sort El-Heneidy, Asmaa
collection PubMed
description BACKGROUND: Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor. METHODS: In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains. RESULTS: Collectively, both ribonucleic acid and deoxyribonucleic acid viruses were negatively associated with RotaTeq shedding (adjusted odds ratio = 0.29, 95% confidence interval = 0.14–0.58 and adjusted odds ratio = 0.30, 95% confidence interval = 0.11–0.78, respectively). CONCLUSIONS: Enteric viruses may interfere with RotaTeq replication in the gut and thus RotaTeq stool shedding.
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spelling pubmed-105474572023-10-04 Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort El-Heneidy, Asmaa Grimwood, Keith Lambert, Stephen B Ware, Robert S J Infect Dis Brief Report BACKGROUND: Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor. METHODS: In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains. RESULTS: Collectively, both ribonucleic acid and deoxyribonucleic acid viruses were negatively associated with RotaTeq shedding (adjusted odds ratio = 0.29, 95% confidence interval = 0.14–0.58 and adjusted odds ratio = 0.30, 95% confidence interval = 0.11–0.78, respectively). CONCLUSIONS: Enteric viruses may interfere with RotaTeq replication in the gut and thus RotaTeq stool shedding. Oxford University Press 2023-04-04 /pmc/articles/PMC10547457/ /pubmed/37014728 http://dx.doi.org/10.1093/infdis/jiad094 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
El-Heneidy, Asmaa
Grimwood, Keith
Lambert, Stephen B
Ware, Robert S
Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort
title Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort
title_full Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort
title_fullStr Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort
title_full_unstemmed Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort
title_short Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort
title_sort interference between enteric viruses and live-attenuated rotavirus vaccine virus in a healthy australian birth cohort
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547457/
https://www.ncbi.nlm.nih.gov/pubmed/37014728
http://dx.doi.org/10.1093/infdis/jiad094
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