MRI-guided focused ultrasound blood–brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest pediatric brainstem tumor and is difficult to treat with chemotherapy in part due to the blood–brain barrier (BBB). Focused ultrasound (FUS) and microbubbles (MBs) have been shown to cause BBB opening, allowing larg...

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Detalles Bibliográficos
Autores principales: Martinez, Payton, Nault, Genna, Steiner, Jenna, Wempe, Michael F, Pierce, Angela, Brunt, Breauna, Slade, Mathew, Song, Jane J, Mongin, Andrew, Song, Kang-Ho, Ellens, Nicholas, Serkova, Natalie, Green, Adam L, Borden, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547466/
https://www.ncbi.nlm.nih.gov/pubmed/37795179
http://dx.doi.org/10.1093/noajnl/vdad111

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