Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

Anti-tumor drug resistance is a challenge for human triple-negative breast cancer (TNBC) treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote TNBC cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found...

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Detalles Bibliográficos
Autores principales: Fang, Huan, Ren, Wenlong, Cui, Qiuxia, Liang, Huichun, Yang, Chuanyu, Liu, Wenjing, Wang, Xinye, Liu, Xue, Shi, Yujie, Feng, Jing, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547475/
https://www.ncbi.nlm.nih.gov/pubmed/37787041
http://dx.doi.org/10.7554/eLife.88483
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author Fang, Huan
Ren, Wenlong
Cui, Qiuxia
Liang, Huichun
Yang, Chuanyu
Liu, Wenjing
Wang, Xinye
Liu, Xue
Shi, Yujie
Feng, Jing
Chen, Ceshi
author_facet Fang, Huan
Ren, Wenlong
Cui, Qiuxia
Liang, Huichun
Yang, Chuanyu
Liu, Wenjing
Wang, Xinye
Liu, Xue
Shi, Yujie
Feng, Jing
Chen, Ceshi
author_sort Fang, Huan
collection PubMed
description Anti-tumor drug resistance is a challenge for human triple-negative breast cancer (TNBC) treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote TNBC cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin β4. Integrin β4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in TNBC. These results indicate that the Integrin β4/TNFAIP2/IQGAP1/RAC1 axis provides potential therapeutic targets to overcome DNA damage-related drug resistance in TNBC.
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spelling pubmed-105474752023-10-04 Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1 Fang, Huan Ren, Wenlong Cui, Qiuxia Liang, Huichun Yang, Chuanyu Liu, Wenjing Wang, Xinye Liu, Xue Shi, Yujie Feng, Jing Chen, Ceshi eLife Cancer Biology Anti-tumor drug resistance is a challenge for human triple-negative breast cancer (TNBC) treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote TNBC cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin β4. Integrin β4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in TNBC. These results indicate that the Integrin β4/TNFAIP2/IQGAP1/RAC1 axis provides potential therapeutic targets to overcome DNA damage-related drug resistance in TNBC. eLife Sciences Publications, Ltd 2023-10-03 /pmc/articles/PMC10547475/ /pubmed/37787041 http://dx.doi.org/10.7554/eLife.88483 Text en © 2023, Fang, Ren, Cui et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cancer Biology
Fang, Huan
Ren, Wenlong
Cui, Qiuxia
Liang, Huichun
Yang, Chuanyu
Liu, Wenjing
Wang, Xinye
Liu, Xue
Shi, Yujie
Feng, Jing
Chen, Ceshi
Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
title Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
title_full Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
title_fullStr Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
title_full_unstemmed Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
title_short Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
title_sort integrin β4 promotes dna damage-related drug resistance in triple-negative breast cancer via tnfaip2/iqgap1/rac1
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547475/
https://www.ncbi.nlm.nih.gov/pubmed/37787041
http://dx.doi.org/10.7554/eLife.88483
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