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Novel regulators of islet function identified from genetic variation in mouse islet Ca(2+) oscillations

Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca(2+) into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca(2+) dynamics in eight genetically diverse mouse strains...

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Detalles Bibliográficos
Autores principales:	Emfinger, Christopher H, Clark, Lauren E, Yandell, Brian, Schueler, Kathryn L, Simonett, Shane P, Stapleton, Donnie S, Mitok, Kelly A, Merrins, Matthew J, Keller, Mark P, Attie, Alan D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547476/ https://www.ncbi.nlm.nih.gov/pubmed/37787501 http://dx.doi.org/10.7554/eLife.88189

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