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Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study
OBJECTIVE: Sickle cell disease is the most frequent of the hereditary hemoglobinopathies and it presents multisystemic effects. A manifestation that is commonly found in sickle cell disease is upper airway obstruction, particularly adenotonsillar hypertrophy. This study aims to evaluate the peak nas...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação Médica Brasileira
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547482/ https://www.ncbi.nlm.nih.gov/pubmed/37792864 http://dx.doi.org/10.1590/1806-9282.20210819 |
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author | Vieira, Ana Karine Alvim, Cristina Gonçalves Braga, Clara Polito Dinardi, Ricardo Reis Borba, Marcos Vinícius Domingues Rodrigues, Ricardo Manoel Oliveira Ibiapina, Cássio da Cunha |
author_facet | Vieira, Ana Karine Alvim, Cristina Gonçalves Braga, Clara Polito Dinardi, Ricardo Reis Borba, Marcos Vinícius Domingues Rodrigues, Ricardo Manoel Oliveira Ibiapina, Cássio da Cunha |
author_sort | Vieira, Ana Karine |
collection | PubMed |
description | OBJECTIVE: Sickle cell disease is the most frequent of the hereditary hemoglobinopathies and it presents multisystemic effects. A manifestation that is commonly found in sickle cell disease is upper airway obstruction, particularly adenotonsillar hypertrophy. This study aims to evaluate the peak nasal inspiratory flow measurements of children and adolescents with sickle cell disease. METHODS: This is a case-control study on children aged between 8 and 15 years who were diagnosed with sickle cell disease. Peak nasal inspiratory flow measurements were obtained from patients. RESULTS: A total of 279 patients were enrolled in this study, with 93 in the case group and 186 in the control group. The case group had an 82.83% chance of having lower peak nasal inspiratory flow values than the control group. In the case group, 75% of the peak nasal inspiratory flow values were in the lower standards, whereas in the control group, only 25% were in the lower standards. CONCLUSION: This study showed a high prevalence of reduced peak nasal inspiratory flow values in children with sickle cell disease and could certainly be incorporated into the day-to-day clinical evaluation of patients as a screening instrument. |
format | Online Article Text |
id | pubmed-10547482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Associação Médica Brasileira |
record_format | MEDLINE/PubMed |
spelling | pubmed-105474822023-10-04 Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study Vieira, Ana Karine Alvim, Cristina Gonçalves Braga, Clara Polito Dinardi, Ricardo Reis Borba, Marcos Vinícius Domingues Rodrigues, Ricardo Manoel Oliveira Ibiapina, Cássio da Cunha Rev Assoc Med Bras (1992) Original Article OBJECTIVE: Sickle cell disease is the most frequent of the hereditary hemoglobinopathies and it presents multisystemic effects. A manifestation that is commonly found in sickle cell disease is upper airway obstruction, particularly adenotonsillar hypertrophy. This study aims to evaluate the peak nasal inspiratory flow measurements of children and adolescents with sickle cell disease. METHODS: This is a case-control study on children aged between 8 and 15 years who were diagnosed with sickle cell disease. Peak nasal inspiratory flow measurements were obtained from patients. RESULTS: A total of 279 patients were enrolled in this study, with 93 in the case group and 186 in the control group. The case group had an 82.83% chance of having lower peak nasal inspiratory flow values than the control group. In the case group, 75% of the peak nasal inspiratory flow values were in the lower standards, whereas in the control group, only 25% were in the lower standards. CONCLUSION: This study showed a high prevalence of reduced peak nasal inspiratory flow values in children with sickle cell disease and could certainly be incorporated into the day-to-day clinical evaluation of patients as a screening instrument. Associação Médica Brasileira 2023-09-25 /pmc/articles/PMC10547482/ /pubmed/37792864 http://dx.doi.org/10.1590/1806-9282.20210819 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Vieira, Ana Karine Alvim, Cristina Gonçalves Braga, Clara Polito Dinardi, Ricardo Reis Borba, Marcos Vinícius Domingues Rodrigues, Ricardo Manoel Oliveira Ibiapina, Cássio da Cunha Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
title | Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
title_full | Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
title_fullStr | Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
title_full_unstemmed | Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
title_short | Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
title_sort | peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547482/ https://www.ncbi.nlm.nih.gov/pubmed/37792864 http://dx.doi.org/10.1590/1806-9282.20210819 |
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