ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome

Paraneoplastic Cushing's syndrome arises when neuroendocrine tumors cause excess glucocorticoid production. We report a case of ectopic ACTH-producing liver neuroendocrine tumor. A 71 y.o. female with a history of rectal squamous carcinoma presented with fatigue and diffuse swelling. Liver biop...

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Detalles Bibliográficos
Autores principales: Sandozi, Mudassar, Pamulapati, Saagar, Zaidi, Aniqa, Stuart, Zuzanna, Pamulapati, Sneha, Doniparthi, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547567/
https://www.ncbi.nlm.nih.gov/pubmed/37794851
http://dx.doi.org/10.1155/2023/9946271
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author Sandozi, Mudassar
Pamulapati, Saagar
Zaidi, Aniqa
Stuart, Zuzanna
Pamulapati, Sneha
Doniparthi, Ajay
author_facet Sandozi, Mudassar
Pamulapati, Saagar
Zaidi, Aniqa
Stuart, Zuzanna
Pamulapati, Sneha
Doniparthi, Ajay
author_sort Sandozi, Mudassar
collection PubMed
description Paraneoplastic Cushing's syndrome arises when neuroendocrine tumors cause excess glucocorticoid production. We report a case of ectopic ACTH-producing liver neuroendocrine tumor. A 71 y.o. female with a history of rectal squamous carcinoma presented with fatigue and diffuse swelling. Liver biopsy revealed metastatic neuroendocrine carcinoma. Workup revealed markedly elevated morning cortisol and ACTH. Overnight dexamethasone suppression testing and positive immunostaining for ACTH on biopsy suggested paraneoplastic Cushing's syndrome secondary to neuroendocrine hepatic tumors with bony metastasis. This explained the patient's persistent anasarca, hyperglycemia, and electrolyte abnormalities. Despite multiple interventions, the patient's clinical status declined, and she expired.
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spelling pubmed-105475672023-10-04 ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome Sandozi, Mudassar Pamulapati, Saagar Zaidi, Aniqa Stuart, Zuzanna Pamulapati, Sneha Doniparthi, Ajay Case Rep Oncol Med Case Report Paraneoplastic Cushing's syndrome arises when neuroendocrine tumors cause excess glucocorticoid production. We report a case of ectopic ACTH-producing liver neuroendocrine tumor. A 71 y.o. female with a history of rectal squamous carcinoma presented with fatigue and diffuse swelling. Liver biopsy revealed metastatic neuroendocrine carcinoma. Workup revealed markedly elevated morning cortisol and ACTH. Overnight dexamethasone suppression testing and positive immunostaining for ACTH on biopsy suggested paraneoplastic Cushing's syndrome secondary to neuroendocrine hepatic tumors with bony metastasis. This explained the patient's persistent anasarca, hyperglycemia, and electrolyte abnormalities. Despite multiple interventions, the patient's clinical status declined, and she expired. Hindawi 2023-09-26 /pmc/articles/PMC10547567/ /pubmed/37794851 http://dx.doi.org/10.1155/2023/9946271 Text en Copyright © 2023 Mudassar Sandozi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sandozi, Mudassar
Pamulapati, Saagar
Zaidi, Aniqa
Stuart, Zuzanna
Pamulapati, Sneha
Doniparthi, Ajay
ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome
title ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome
title_full ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome
title_fullStr ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome
title_full_unstemmed ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome
title_short ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome
title_sort acth-producing neuroendocrine carcinoma of the liver with cushing's syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547567/
https://www.ncbi.nlm.nih.gov/pubmed/37794851
http://dx.doi.org/10.1155/2023/9946271
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