The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil

The epigenetic modifier histone deacetylase-2 (HDAC2) is frequently dysregulated in colon cancer cells. Microsatellite instability (MSI), an unfaithful replication of DNA at nucleotide repeats, occurs in about 15% of human colon tumors. MSI promotes a genetic frameshift and consequently a loss of HD...

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Detalles Bibliográficos
Autores principales: Kiweler, Nicole, Schwarz, Helena, Nguyen, Alexandra, Matschos, Stephanie, Mullins, Christina, Piée-Staffa, Andrea, Brachetti, Christina, Roos, Wynand P., Schneider, Günter, Linnebacher, Michael, Brenner, Walburgis, Krämer, Oliver H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547618/
https://www.ncbi.nlm.nih.gov/pubmed/35608750
http://dx.doi.org/10.1007/s10565-022-09731-3

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