Research Progress on Pyroptosis in Hematological Malignancies

Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have shown that pyroptosis can be involved in the pathological processes of many diseases, such as cancers, atherosclerosis, diabetic nephropathy, and blood di...

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Autores principales: Lyu, Tianxin, Yin, Qingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547621/
https://www.ncbi.nlm.nih.gov/pubmed/37635159
http://dx.doi.org/10.1007/s11864-023-01119-7
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author Lyu, Tianxin
Yin, Qingsong
author_facet Lyu, Tianxin
Yin, Qingsong
author_sort Lyu, Tianxin
collection PubMed
description Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have shown that pyroptosis can be involved in the pathological processes of many diseases, such as cancers, atherosclerosis, diabetic nephropathy, and blood diseases. However, the specific mechanisms by which pyroptosis participates in the occurrence and development of hematological malignant tumors still need further exploration. This article reviews the characteristics of pyroptosis and the regulatory mechanisms promoting or inhibiting pyroptosis and discusses the role of pyroptosis in hematological malignant tumors, which could provide ideas for the clinical treatment of such tumors in the future.
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spelling pubmed-105476212023-10-05 Research Progress on Pyroptosis in Hematological Malignancies Lyu, Tianxin Yin, Qingsong Curr Treat Options Oncol Article Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have shown that pyroptosis can be involved in the pathological processes of many diseases, such as cancers, atherosclerosis, diabetic nephropathy, and blood diseases. However, the specific mechanisms by which pyroptosis participates in the occurrence and development of hematological malignant tumors still need further exploration. This article reviews the characteristics of pyroptosis and the regulatory mechanisms promoting or inhibiting pyroptosis and discusses the role of pyroptosis in hematological malignant tumors, which could provide ideas for the clinical treatment of such tumors in the future. Springer US 2023-08-28 2023 /pmc/articles/PMC10547621/ /pubmed/37635159 http://dx.doi.org/10.1007/s11864-023-01119-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lyu, Tianxin
Yin, Qingsong
Research Progress on Pyroptosis in Hematological Malignancies
title Research Progress on Pyroptosis in Hematological Malignancies
title_full Research Progress on Pyroptosis in Hematological Malignancies
title_fullStr Research Progress on Pyroptosis in Hematological Malignancies
title_full_unstemmed Research Progress on Pyroptosis in Hematological Malignancies
title_short Research Progress on Pyroptosis in Hematological Malignancies
title_sort research progress on pyroptosis in hematological malignancies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547621/
https://www.ncbi.nlm.nih.gov/pubmed/37635159
http://dx.doi.org/10.1007/s11864-023-01119-7
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