SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters

PURPOSE: To construct a detailed mechanistic and physiologically based biopharmaceutics model capable of predicting 1) device-formulation-tissue interaction during the injection process and 2) binding, degradation, local distribution, diffusion, and drug absorption, following subcutaneous injection....

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Detalles Bibliográficos
Autores principales: Pepin, Xavier J. H., Grant, Iain, Wood, J. Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547635/
https://www.ncbi.nlm.nih.gov/pubmed/37634241
http://dx.doi.org/10.1007/s11095-023-03567-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547635/
https://www.ncbi.nlm.nih.gov/pubmed/37634241
http://dx.doi.org/10.1007/s11095-023-03567-0

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