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Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy
Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we data-mined human and mouse heart ribosome profiling analyses and identified a double-stranded RNA (dsRNA) structur...
Autores principales: | Hedaya, Omar M., Venkata Subbaiah, Kadiam C., Jiang, Feng, Xie, Li Huitong, Wu, Jiangbin, Khor, Eng-Soon, Zhu, Mingyi, Mathews, David H., Proschel, Chris, Yao, Peng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547706/ https://www.ncbi.nlm.nih.gov/pubmed/37789015 http://dx.doi.org/10.1038/s41467-023-41799-1 |
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