Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

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Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we data-mined human and mouse heart ribosome profiling analyses and identified a double-stranded RNA (dsRNA) structur...

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Detalles Bibliográficos
Autores principales: Hedaya, Omar M., Venkata Subbaiah, Kadiam C., Jiang, Feng, Xie, Li Huitong, Wu, Jiangbin, Khor, Eng-Soon, Zhu, Mingyi, Mathews, David H., Proschel, Chris, Yao, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547706/
https://www.ncbi.nlm.nih.gov/pubmed/37789015
http://dx.doi.org/10.1038/s41467-023-41799-1
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