The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance

Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understandi...

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Autores principales: Cavany, Sean, Nanyonga, Stella, Hauk, Cathrin, Lim, Cherry, Tarning, Joel, Sartorius, Benn, Dolecek, Christiane, Caillet, Céline, Newton, Paul N., Cooper, Ben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547756/
https://www.ncbi.nlm.nih.gov/pubmed/37788991
http://dx.doi.org/10.1038/s41467-023-41542-w
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author Cavany, Sean
Nanyonga, Stella
Hauk, Cathrin
Lim, Cherry
Tarning, Joel
Sartorius, Benn
Dolecek, Christiane
Caillet, Céline
Newton, Paul N.
Cooper, Ben S.
author_facet Cavany, Sean
Nanyonga, Stella
Hauk, Cathrin
Lim, Cherry
Tarning, Joel
Sartorius, Benn
Dolecek, Christiane
Caillet, Céline
Newton, Paul N.
Cooper, Ben S.
author_sort Cavany, Sean
collection PubMed
description Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understanding of this relationship remains rudimentary. Substandard and falsified medicines have the potential to either increase or decrease levels of resistance, and here we discuss a range of mechanisms that could drive these changes. Understanding these effects and their relative importance will require an improved understanding of how different drug exposures affect the emergence and spread of resistance and of how the percentage of active pharmaceutical ingredients in substandard and falsified medicines is temporally and spatially distributed.
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spelling pubmed-105477562023-10-05 The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance Cavany, Sean Nanyonga, Stella Hauk, Cathrin Lim, Cherry Tarning, Joel Sartorius, Benn Dolecek, Christiane Caillet, Céline Newton, Paul N. Cooper, Ben S. Nat Commun Perspective Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understanding of this relationship remains rudimentary. Substandard and falsified medicines have the potential to either increase or decrease levels of resistance, and here we discuss a range of mechanisms that could drive these changes. Understanding these effects and their relative importance will require an improved understanding of how different drug exposures affect the emergence and spread of resistance and of how the percentage of active pharmaceutical ingredients in substandard and falsified medicines is temporally and spatially distributed. Nature Publishing Group UK 2023-10-03 /pmc/articles/PMC10547756/ /pubmed/37788991 http://dx.doi.org/10.1038/s41467-023-41542-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Cavany, Sean
Nanyonga, Stella
Hauk, Cathrin
Lim, Cherry
Tarning, Joel
Sartorius, Benn
Dolecek, Christiane
Caillet, Céline
Newton, Paul N.
Cooper, Ben S.
The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
title The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
title_full The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
title_fullStr The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
title_full_unstemmed The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
title_short The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
title_sort uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547756/
https://www.ncbi.nlm.nih.gov/pubmed/37788991
http://dx.doi.org/10.1038/s41467-023-41542-w
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