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ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway

Persistent myocardial hypertrophy frequently leads to heart failure (HF). Intramyocardial triacylglycerol (TAG) accumulation is closely related with cardiac remodeling and abnormal contractile function. Adipose triglyceride lipase (ATGL), a key enzyme in TAG metabolism, regulates cardiac function. H...

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Detalles Bibliográficos
Autores principales:	Han, Xiao, Zhang, Yun-Long, Lin, Qiu-Yue, Li, Hui-Hua, Guo, Shu-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547847/ https://www.ncbi.nlm.nih.gov/pubmed/35218467 http://dx.doi.org/10.1007/s10565-022-09699-0

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