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Protracted complete response after limited checkpoint inhibitor dosing: A case report

Immunotherapy is an important modality in the treatment of many types of malignancy. The optimal duration of treatment with immunotherapy in patients with metastatic malignancies who experience complete responses is not fully understood. Our case demonstrates a protracted complete response in a pati...

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Detalles Bibliográficos
Autores principales: Sember, Quinne, Sigal, Darren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547855/
https://www.ncbi.nlm.nih.gov/pubmed/37799570
http://dx.doi.org/10.1002/ccr3.7793
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author Sember, Quinne
Sigal, Darren
author_facet Sember, Quinne
Sigal, Darren
author_sort Sember, Quinne
collection PubMed
description Immunotherapy is an important modality in the treatment of many types of malignancy. The optimal duration of treatment with immunotherapy in patients with metastatic malignancies who experience complete responses is not fully understood. Our case demonstrates a protracted complete response in a patient with metastatic gastric adenocarcinoma after just three doses of pembrolizumab. This illustrates a need for further research into which patients might have responses such as these and could therefore be spared additional doses of an expensive treatment with many potential side effects.
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spelling pubmed-105478552023-10-05 Protracted complete response after limited checkpoint inhibitor dosing: A case report Sember, Quinne Sigal, Darren Clin Case Rep Case Report Immunotherapy is an important modality in the treatment of many types of malignancy. The optimal duration of treatment with immunotherapy in patients with metastatic malignancies who experience complete responses is not fully understood. Our case demonstrates a protracted complete response in a patient with metastatic gastric adenocarcinoma after just three doses of pembrolizumab. This illustrates a need for further research into which patients might have responses such as these and could therefore be spared additional doses of an expensive treatment with many potential side effects. John Wiley and Sons Inc. 2023-10-03 /pmc/articles/PMC10547855/ /pubmed/37799570 http://dx.doi.org/10.1002/ccr3.7793 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Sember, Quinne
Sigal, Darren
Protracted complete response after limited checkpoint inhibitor dosing: A case report
title Protracted complete response after limited checkpoint inhibitor dosing: A case report
title_full Protracted complete response after limited checkpoint inhibitor dosing: A case report
title_fullStr Protracted complete response after limited checkpoint inhibitor dosing: A case report
title_full_unstemmed Protracted complete response after limited checkpoint inhibitor dosing: A case report
title_short Protracted complete response after limited checkpoint inhibitor dosing: A case report
title_sort protracted complete response after limited checkpoint inhibitor dosing: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547855/
https://www.ncbi.nlm.nih.gov/pubmed/37799570
http://dx.doi.org/10.1002/ccr3.7793
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