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Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis

BACKGROUND: Observational studies have reported the association between fatigue and coronary artery disease (CAD), but the causal association between fatigue and CAD is unclear. METHOD: We conducted a bidirectional Mendelian randomization (MR) study using publicly available genome-wide association s...

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Autores principales: Qi, Xiaoyi, Wang, Shijia, Qiu, Liangxian, Chen, Xiongbiao, Huang, Qianwen, Ouyang, Kunfu, Chen, Yanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547863/
https://www.ncbi.nlm.nih.gov/pubmed/37799396
http://dx.doi.org/10.3389/fpsyt.2023.1166689
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author Qi, Xiaoyi
Wang, Shijia
Qiu, Liangxian
Chen, Xiongbiao
Huang, Qianwen
Ouyang, Kunfu
Chen, Yanjun
author_facet Qi, Xiaoyi
Wang, Shijia
Qiu, Liangxian
Chen, Xiongbiao
Huang, Qianwen
Ouyang, Kunfu
Chen, Yanjun
author_sort Qi, Xiaoyi
collection PubMed
description BACKGROUND: Observational studies have reported the association between fatigue and coronary artery disease (CAD), but the causal association between fatigue and CAD is unclear. METHOD: We conducted a bidirectional Mendelian randomization (MR) study using publicly available genome-wide association studies (GWAS) data. The inverse-variance weighted (IVW) method was used as the primary analysis. We performed three complementary methods, including weighted median, MR-Egger regression, and MR pleiotropy residual sum and outlier (MR-PRESSO) to evaluate the sensitivity and horizontal pleiotropy of the results. RESULT: Self-reported fatigue had a causal effect on coronary artery atherosclerosis (CAA) (OR 1.047, 95%CI 1.033–1.062), myocardial infarction (MI) (OR 1.027 95%CI 1.014–1.039) and coronary heart disease (CHD) (OR 1.037, 95%CI 1.021–1.053). We did not find a significant reverse causality between self-reported fatigue and CAD. Given the heterogeneity revealed by MR-Egger regression, we employed the IVW random effect model. For the examination of fatigue on CHD and the reverse analysis of CAA, and MI on fatigue, the MR-PRESSO test found horizontal pleiotropy. No significant outliers were found. CONCLUSION: The MR analysis reveals a causal relationship between self-reported fatigue and CAD. The results should be interpreted with caution due to horizontal pleiotropy.
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spelling pubmed-105478632023-10-05 Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis Qi, Xiaoyi Wang, Shijia Qiu, Liangxian Chen, Xiongbiao Huang, Qianwen Ouyang, Kunfu Chen, Yanjun Front Psychiatry Psychiatry BACKGROUND: Observational studies have reported the association between fatigue and coronary artery disease (CAD), but the causal association between fatigue and CAD is unclear. METHOD: We conducted a bidirectional Mendelian randomization (MR) study using publicly available genome-wide association studies (GWAS) data. The inverse-variance weighted (IVW) method was used as the primary analysis. We performed three complementary methods, including weighted median, MR-Egger regression, and MR pleiotropy residual sum and outlier (MR-PRESSO) to evaluate the sensitivity and horizontal pleiotropy of the results. RESULT: Self-reported fatigue had a causal effect on coronary artery atherosclerosis (CAA) (OR 1.047, 95%CI 1.033–1.062), myocardial infarction (MI) (OR 1.027 95%CI 1.014–1.039) and coronary heart disease (CHD) (OR 1.037, 95%CI 1.021–1.053). We did not find a significant reverse causality between self-reported fatigue and CAD. Given the heterogeneity revealed by MR-Egger regression, we employed the IVW random effect model. For the examination of fatigue on CHD and the reverse analysis of CAA, and MI on fatigue, the MR-PRESSO test found horizontal pleiotropy. No significant outliers were found. CONCLUSION: The MR analysis reveals a causal relationship between self-reported fatigue and CAD. The results should be interpreted with caution due to horizontal pleiotropy. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10547863/ /pubmed/37799396 http://dx.doi.org/10.3389/fpsyt.2023.1166689 Text en Copyright © 2023 Qi, Wang, Qiu, Chen, Huang, Ouyang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Qi, Xiaoyi
Wang, Shijia
Qiu, Liangxian
Chen, Xiongbiao
Huang, Qianwen
Ouyang, Kunfu
Chen, Yanjun
Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
title Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
title_full Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
title_fullStr Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
title_full_unstemmed Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
title_short Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
title_sort causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample mendelian randomization analysis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547863/
https://www.ncbi.nlm.nih.gov/pubmed/37799396
http://dx.doi.org/10.3389/fpsyt.2023.1166689
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