Cargando…

Emerging roles of proximal tubular endocytosis in renal fibrosis

Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. G...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Min, Gu, Xiangchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547866/
https://www.ncbi.nlm.nih.gov/pubmed/37799275
http://dx.doi.org/10.3389/fcell.2023.1235716
_version_ 1785115149690994688
author Chen, Min
Gu, Xiangchen
author_facet Chen, Min
Gu, Xiangchen
author_sort Chen, Min
collection PubMed
description Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect the proximal tubule endocytosis processes, by disturbing or overstressing the endolysosomal system and subsequently activating different pathways, orchestrating renal fibrosis. This paper will review recent studies on proximal tubular endocytosis affected by other diseases and factors. Endocytosis plays a vital role in the development of renal fibrosis, and renal fibrosis could also, in turn, affect tubular endocytosis.
format Online
Article
Text
id pubmed-10547866
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105478662023-10-05 Emerging roles of proximal tubular endocytosis in renal fibrosis Chen, Min Gu, Xiangchen Front Cell Dev Biol Cell and Developmental Biology Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect the proximal tubule endocytosis processes, by disturbing or overstressing the endolysosomal system and subsequently activating different pathways, orchestrating renal fibrosis. This paper will review recent studies on proximal tubular endocytosis affected by other diseases and factors. Endocytosis plays a vital role in the development of renal fibrosis, and renal fibrosis could also, in turn, affect tubular endocytosis. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10547866/ /pubmed/37799275 http://dx.doi.org/10.3389/fcell.2023.1235716 Text en Copyright © 2023 Chen and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Min
Gu, Xiangchen
Emerging roles of proximal tubular endocytosis in renal fibrosis
title Emerging roles of proximal tubular endocytosis in renal fibrosis
title_full Emerging roles of proximal tubular endocytosis in renal fibrosis
title_fullStr Emerging roles of proximal tubular endocytosis in renal fibrosis
title_full_unstemmed Emerging roles of proximal tubular endocytosis in renal fibrosis
title_short Emerging roles of proximal tubular endocytosis in renal fibrosis
title_sort emerging roles of proximal tubular endocytosis in renal fibrosis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547866/
https://www.ncbi.nlm.nih.gov/pubmed/37799275
http://dx.doi.org/10.3389/fcell.2023.1235716
work_keys_str_mv AT chenmin emergingrolesofproximaltubularendocytosisinrenalfibrosis
AT guxiangchen emergingrolesofproximaltubularendocytosisinrenalfibrosis