Cargando…
Emerging roles of proximal tubular endocytosis in renal fibrosis
Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. G...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547866/ https://www.ncbi.nlm.nih.gov/pubmed/37799275 http://dx.doi.org/10.3389/fcell.2023.1235716 |
_version_ | 1785115149690994688 |
---|---|
author | Chen, Min Gu, Xiangchen |
author_facet | Chen, Min Gu, Xiangchen |
author_sort | Chen, Min |
collection | PubMed |
description | Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect the proximal tubule endocytosis processes, by disturbing or overstressing the endolysosomal system and subsequently activating different pathways, orchestrating renal fibrosis. This paper will review recent studies on proximal tubular endocytosis affected by other diseases and factors. Endocytosis plays a vital role in the development of renal fibrosis, and renal fibrosis could also, in turn, affect tubular endocytosis. |
format | Online Article Text |
id | pubmed-10547866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105478662023-10-05 Emerging roles of proximal tubular endocytosis in renal fibrosis Chen, Min Gu, Xiangchen Front Cell Dev Biol Cell and Developmental Biology Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority of filtered water and glucose, as well as all the proteins filtered through the glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect the proximal tubule endocytosis processes, by disturbing or overstressing the endolysosomal system and subsequently activating different pathways, orchestrating renal fibrosis. This paper will review recent studies on proximal tubular endocytosis affected by other diseases and factors. Endocytosis plays a vital role in the development of renal fibrosis, and renal fibrosis could also, in turn, affect tubular endocytosis. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10547866/ /pubmed/37799275 http://dx.doi.org/10.3389/fcell.2023.1235716 Text en Copyright © 2023 Chen and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Chen, Min Gu, Xiangchen Emerging roles of proximal tubular endocytosis in renal fibrosis |
title | Emerging roles of proximal tubular endocytosis in renal fibrosis |
title_full | Emerging roles of proximal tubular endocytosis in renal fibrosis |
title_fullStr | Emerging roles of proximal tubular endocytosis in renal fibrosis |
title_full_unstemmed | Emerging roles of proximal tubular endocytosis in renal fibrosis |
title_short | Emerging roles of proximal tubular endocytosis in renal fibrosis |
title_sort | emerging roles of proximal tubular endocytosis in renal fibrosis |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547866/ https://www.ncbi.nlm.nih.gov/pubmed/37799275 http://dx.doi.org/10.3389/fcell.2023.1235716 |
work_keys_str_mv | AT chenmin emergingrolesofproximaltubularendocytosisinrenalfibrosis AT guxiangchen emergingrolesofproximaltubularendocytosisinrenalfibrosis |