Cargando…

The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refract...

Descripción completa

Detalles Bibliográficos
Autores principales: Velasco, Pablo, Bautista, Francisco, Rubio, Alba, Aguilar, Yurena, Rives, Susana, Dapena, Jose L., Pérez, Antonio, Ramirez, Manuel, Saiz-Ladera, Cristina, Izquierdo, Elisa, Escudero, Adela, Camós, Mireia, Vega-García, Nerea, Ortega, Margarita, Hidalgo-Gómez, Gloria, Palacio, Carlos, Menéndez, Pablo, Bueno, Clara, Montero, Joan, Romecín, Paola A., Zazo, Santiago, Alvarez, Federico, Parras, Juan, Ortega-Sabater, Carmen, Chulián, Salvador, Rosa, María, Cirillo, Davide, García, Elena, García, Jorge, Manzano-Muñoz, Albert, Minguela, Alfredo, Fuster, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547895/
https://www.ncbi.nlm.nih.gov/pubmed/37800011
http://dx.doi.org/10.3389/fped.2023.1269560
_version_ 1785115156548681728
author Velasco, Pablo
Bautista, Francisco
Rubio, Alba
Aguilar, Yurena
Rives, Susana
Dapena, Jose L.
Pérez, Antonio
Ramirez, Manuel
Saiz-Ladera, Cristina
Izquierdo, Elisa
Escudero, Adela
Camós, Mireia
Vega-García, Nerea
Ortega, Margarita
Hidalgo-Gómez, Gloria
Palacio, Carlos
Menéndez, Pablo
Bueno, Clara
Montero, Joan
Romecín, Paola A.
Zazo, Santiago
Alvarez, Federico
Parras, Juan
Ortega-Sabater, Carmen
Chulián, Salvador
Rosa, María
Cirillo, Davide
García, Elena
García, Jorge
Manzano-Muñoz, Albert
Minguela, Alfredo
Fuster, Jose L.
author_facet Velasco, Pablo
Bautista, Francisco
Rubio, Alba
Aguilar, Yurena
Rives, Susana
Dapena, Jose L.
Pérez, Antonio
Ramirez, Manuel
Saiz-Ladera, Cristina
Izquierdo, Elisa
Escudero, Adela
Camós, Mireia
Vega-García, Nerea
Ortega, Margarita
Hidalgo-Gómez, Gloria
Palacio, Carlos
Menéndez, Pablo
Bueno, Clara
Montero, Joan
Romecín, Paola A.
Zazo, Santiago
Alvarez, Federico
Parras, Juan
Ortega-Sabater, Carmen
Chulián, Salvador
Rosa, María
Cirillo, Davide
García, Elena
García, Jorge
Manzano-Muñoz, Albert
Minguela, Alfredo
Fuster, Jose L.
author_sort Velasco, Pablo
collection PubMed
description Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refractory ALL (R/R ALL). Driven by this context and following the European strategic plan to implement precision medicine equitably, the Relapsed ALL Network (ReALLNet) was launched under the umbrella of SEHOP in 2021, aiming to connect bedside patient care with expert groups in R/R ALL in an interdisciplinary and multicentric network. To achieve this objective, a board consisting of experts in diagnosis, management, preclinical research, and clinical trials has been established. The requirements of treatment centers have been evaluated, and the available oncogenomic and functional study resources have been assessed and organized. A shipping platform has been developed to process samples requiring study derivation, and an integrated diagnostic committee has been established to report results. These biological data, as well as patient outcomes, are collected in a national registry. Additionally, samples from all patients are stored in a biobank. This comprehensive repository of data and samples is expected to foster an environment where preclinical researchers and data scientists can seek to meet the complex needs of this challenging population. This proof of concept aims to demonstrate that a network-based organization, such as that embodied by ReALLNet, provides the ideal niche for the equitable and efficient implementation of “what's next” in the management of children with R/R ALL.
format Online
Article
Text
id pubmed-10547895
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105478952023-10-05 The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) Velasco, Pablo Bautista, Francisco Rubio, Alba Aguilar, Yurena Rives, Susana Dapena, Jose L. Pérez, Antonio Ramirez, Manuel Saiz-Ladera, Cristina Izquierdo, Elisa Escudero, Adela Camós, Mireia Vega-García, Nerea Ortega, Margarita Hidalgo-Gómez, Gloria Palacio, Carlos Menéndez, Pablo Bueno, Clara Montero, Joan Romecín, Paola A. Zazo, Santiago Alvarez, Federico Parras, Juan Ortega-Sabater, Carmen Chulián, Salvador Rosa, María Cirillo, Davide García, Elena García, Jorge Manzano-Muñoz, Albert Minguela, Alfredo Fuster, Jose L. Front Pediatr Pediatrics Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refractory ALL (R/R ALL). Driven by this context and following the European strategic plan to implement precision medicine equitably, the Relapsed ALL Network (ReALLNet) was launched under the umbrella of SEHOP in 2021, aiming to connect bedside patient care with expert groups in R/R ALL in an interdisciplinary and multicentric network. To achieve this objective, a board consisting of experts in diagnosis, management, preclinical research, and clinical trials has been established. The requirements of treatment centers have been evaluated, and the available oncogenomic and functional study resources have been assessed and organized. A shipping platform has been developed to process samples requiring study derivation, and an integrated diagnostic committee has been established to report results. These biological data, as well as patient outcomes, are collected in a national registry. Additionally, samples from all patients are stored in a biobank. This comprehensive repository of data and samples is expected to foster an environment where preclinical researchers and data scientists can seek to meet the complex needs of this challenging population. This proof of concept aims to demonstrate that a network-based organization, such as that embodied by ReALLNet, provides the ideal niche for the equitable and efficient implementation of “what's next” in the management of children with R/R ALL. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10547895/ /pubmed/37800011 http://dx.doi.org/10.3389/fped.2023.1269560 Text en © 2023 Velasco, Bautista, Rubio, Aguilar, Rives, Dapena, Pérez, Ramirez, Saiz-Ladera, Izquierdo, Escudero, Camós, Vega-Garcia, Ortega, Hidalgo-Gómez, Palacio, Menéndez, Bueno, Montero, Romecín, Zazo, Alvarez, Parras, Ortega-Sabater, Chulián, Rosa, Cirillo, García, García, Manzano-Muñoz, Minguela and Fuster. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Velasco, Pablo
Bautista, Francisco
Rubio, Alba
Aguilar, Yurena
Rives, Susana
Dapena, Jose L.
Pérez, Antonio
Ramirez, Manuel
Saiz-Ladera, Cristina
Izquierdo, Elisa
Escudero, Adela
Camós, Mireia
Vega-García, Nerea
Ortega, Margarita
Hidalgo-Gómez, Gloria
Palacio, Carlos
Menéndez, Pablo
Bueno, Clara
Montero, Joan
Romecín, Paola A.
Zazo, Santiago
Alvarez, Federico
Parras, Juan
Ortega-Sabater, Carmen
Chulián, Salvador
Rosa, María
Cirillo, Davide
García, Elena
García, Jorge
Manzano-Muñoz, Albert
Minguela, Alfredo
Fuster, Jose L.
The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
title The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
title_full The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
title_fullStr The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
title_full_unstemmed The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
title_short The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
title_sort relapsed acute lymphoblastic leukemia network (reallnet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (sehop)
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547895/
https://www.ncbi.nlm.nih.gov/pubmed/37800011
http://dx.doi.org/10.3389/fped.2023.1269560
work_keys_str_mv AT velascopablo therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT bautistafrancisco therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT rubioalba therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT aguilaryurena therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT rivessusana therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT dapenajosel therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT perezantonio therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT ramirezmanuel therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT saizladeracristina therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT izquierdoelisa therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT escuderoadela therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT camosmireia therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT vegagarcianerea therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT ortegamargarita therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT hidalgogomezgloria therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT palaciocarlos therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT menendezpablo therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT buenoclara therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT monterojoan therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT romecinpaolaa therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT zazosantiago therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT alvarezfederico therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT parrasjuan therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT ortegasabatercarmen therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT chuliansalvador therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT rosamaria therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT cirillodavide therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT garciaelena therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT garciajorge therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT manzanomunozalbert therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT minguelaalfredo therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT fusterjosel therelapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT velascopablo relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT bautistafrancisco relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT rubioalba relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT aguilaryurena relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT rivessusana relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT dapenajosel relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT perezantonio relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT ramirezmanuel relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT saizladeracristina relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT izquierdoelisa relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT escuderoadela relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT camosmireia relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT vegagarcianerea relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT ortegamargarita relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT hidalgogomezgloria relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT palaciocarlos relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT menendezpablo relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT buenoclara relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT monterojoan relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT romecinpaolaa relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT zazosantiago relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT alvarezfederico relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT parrasjuan relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT ortegasabatercarmen relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT chuliansalvador relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT rosamaria relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT cirillodavide relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT garciaelena relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT garciajorge relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT manzanomunozalbert relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT minguelaalfredo relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop
AT fusterjosel relapsedacutelymphoblasticleukemianetworkreallnetamultidisciplinaryprojectfromthespanishsocietyofpediatrichematologyandoncologysehop