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The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refract...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547895/ https://www.ncbi.nlm.nih.gov/pubmed/37800011 http://dx.doi.org/10.3389/fped.2023.1269560 |
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author | Velasco, Pablo Bautista, Francisco Rubio, Alba Aguilar, Yurena Rives, Susana Dapena, Jose L. Pérez, Antonio Ramirez, Manuel Saiz-Ladera, Cristina Izquierdo, Elisa Escudero, Adela Camós, Mireia Vega-García, Nerea Ortega, Margarita Hidalgo-Gómez, Gloria Palacio, Carlos Menéndez, Pablo Bueno, Clara Montero, Joan Romecín, Paola A. Zazo, Santiago Alvarez, Federico Parras, Juan Ortega-Sabater, Carmen Chulián, Salvador Rosa, María Cirillo, Davide García, Elena García, Jorge Manzano-Muñoz, Albert Minguela, Alfredo Fuster, Jose L. |
author_facet | Velasco, Pablo Bautista, Francisco Rubio, Alba Aguilar, Yurena Rives, Susana Dapena, Jose L. Pérez, Antonio Ramirez, Manuel Saiz-Ladera, Cristina Izquierdo, Elisa Escudero, Adela Camós, Mireia Vega-García, Nerea Ortega, Margarita Hidalgo-Gómez, Gloria Palacio, Carlos Menéndez, Pablo Bueno, Clara Montero, Joan Romecín, Paola A. Zazo, Santiago Alvarez, Federico Parras, Juan Ortega-Sabater, Carmen Chulián, Salvador Rosa, María Cirillo, Davide García, Elena García, Jorge Manzano-Muñoz, Albert Minguela, Alfredo Fuster, Jose L. |
author_sort | Velasco, Pablo |
collection | PubMed |
description | Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refractory ALL (R/R ALL). Driven by this context and following the European strategic plan to implement precision medicine equitably, the Relapsed ALL Network (ReALLNet) was launched under the umbrella of SEHOP in 2021, aiming to connect bedside patient care with expert groups in R/R ALL in an interdisciplinary and multicentric network. To achieve this objective, a board consisting of experts in diagnosis, management, preclinical research, and clinical trials has been established. The requirements of treatment centers have been evaluated, and the available oncogenomic and functional study resources have been assessed and organized. A shipping platform has been developed to process samples requiring study derivation, and an integrated diagnostic committee has been established to report results. These biological data, as well as patient outcomes, are collected in a national registry. Additionally, samples from all patients are stored in a biobank. This comprehensive repository of data and samples is expected to foster an environment where preclinical researchers and data scientists can seek to meet the complex needs of this challenging population. This proof of concept aims to demonstrate that a network-based organization, such as that embodied by ReALLNet, provides the ideal niche for the equitable and efficient implementation of “what's next” in the management of children with R/R ALL. |
format | Online Article Text |
id | pubmed-10547895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105478952023-10-05 The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) Velasco, Pablo Bautista, Francisco Rubio, Alba Aguilar, Yurena Rives, Susana Dapena, Jose L. Pérez, Antonio Ramirez, Manuel Saiz-Ladera, Cristina Izquierdo, Elisa Escudero, Adela Camós, Mireia Vega-García, Nerea Ortega, Margarita Hidalgo-Gómez, Gloria Palacio, Carlos Menéndez, Pablo Bueno, Clara Montero, Joan Romecín, Paola A. Zazo, Santiago Alvarez, Federico Parras, Juan Ortega-Sabater, Carmen Chulián, Salvador Rosa, María Cirillo, Davide García, Elena García, Jorge Manzano-Muñoz, Albert Minguela, Alfredo Fuster, Jose L. Front Pediatr Pediatrics Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refractory ALL (R/R ALL). Driven by this context and following the European strategic plan to implement precision medicine equitably, the Relapsed ALL Network (ReALLNet) was launched under the umbrella of SEHOP in 2021, aiming to connect bedside patient care with expert groups in R/R ALL in an interdisciplinary and multicentric network. To achieve this objective, a board consisting of experts in diagnosis, management, preclinical research, and clinical trials has been established. The requirements of treatment centers have been evaluated, and the available oncogenomic and functional study resources have been assessed and organized. A shipping platform has been developed to process samples requiring study derivation, and an integrated diagnostic committee has been established to report results. These biological data, as well as patient outcomes, are collected in a national registry. Additionally, samples from all patients are stored in a biobank. This comprehensive repository of data and samples is expected to foster an environment where preclinical researchers and data scientists can seek to meet the complex needs of this challenging population. This proof of concept aims to demonstrate that a network-based organization, such as that embodied by ReALLNet, provides the ideal niche for the equitable and efficient implementation of “what's next” in the management of children with R/R ALL. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10547895/ /pubmed/37800011 http://dx.doi.org/10.3389/fped.2023.1269560 Text en © 2023 Velasco, Bautista, Rubio, Aguilar, Rives, Dapena, Pérez, Ramirez, Saiz-Ladera, Izquierdo, Escudero, Camós, Vega-Garcia, Ortega, Hidalgo-Gómez, Palacio, Menéndez, Bueno, Montero, Romecín, Zazo, Alvarez, Parras, Ortega-Sabater, Chulián, Rosa, Cirillo, García, García, Manzano-Muñoz, Minguela and Fuster. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Velasco, Pablo Bautista, Francisco Rubio, Alba Aguilar, Yurena Rives, Susana Dapena, Jose L. Pérez, Antonio Ramirez, Manuel Saiz-Ladera, Cristina Izquierdo, Elisa Escudero, Adela Camós, Mireia Vega-García, Nerea Ortega, Margarita Hidalgo-Gómez, Gloria Palacio, Carlos Menéndez, Pablo Bueno, Clara Montero, Joan Romecín, Paola A. Zazo, Santiago Alvarez, Federico Parras, Juan Ortega-Sabater, Carmen Chulián, Salvador Rosa, María Cirillo, Davide García, Elena García, Jorge Manzano-Muñoz, Albert Minguela, Alfredo Fuster, Jose L. The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) |
title | The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) |
title_full | The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) |
title_fullStr | The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) |
title_full_unstemmed | The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) |
title_short | The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) |
title_sort | relapsed acute lymphoblastic leukemia network (reallnet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (sehop) |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547895/ https://www.ncbi.nlm.nih.gov/pubmed/37800011 http://dx.doi.org/10.3389/fped.2023.1269560 |
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