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Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report
Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The e...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547897/ https://www.ncbi.nlm.nih.gov/pubmed/37799478 http://dx.doi.org/10.3389/fonc.2023.1244628 |
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author | Castelli, Barbara Fonte, Carla Guidi, Milena Tellini, Marco Di Nicola, Marco Iacono, Alessandro Buccoliero, Anna Maria Greto, Daniela Genitori, Lorenzo Sardi, Iacopo |
author_facet | Castelli, Barbara Fonte, Carla Guidi, Milena Tellini, Marco Di Nicola, Marco Iacono, Alessandro Buccoliero, Anna Maria Greto, Daniela Genitori, Lorenzo Sardi, Iacopo |
author_sort | Castelli, Barbara |
collection | PubMed |
description | Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The efficacy of bevacizumab has also been described in radiation necrosis. Considering the possible overlapping of radiation treatment effect and disease progression and difficulty in differentiating, we report on the use of BEVIRI in a case of a recurrent relapsing low-grade glioma of the pineal region, subjected to multiple neurosurgical interventions, also treated with a carboplatin-etoposide regimen and a radiation course, at present at one-year follow-up showing a stable response, with no adverse events. |
format | Online Article Text |
id | pubmed-10547897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105478972023-10-05 Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report Castelli, Barbara Fonte, Carla Guidi, Milena Tellini, Marco Di Nicola, Marco Iacono, Alessandro Buccoliero, Anna Maria Greto, Daniela Genitori, Lorenzo Sardi, Iacopo Front Oncol Oncology Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The efficacy of bevacizumab has also been described in radiation necrosis. Considering the possible overlapping of radiation treatment effect and disease progression and difficulty in differentiating, we report on the use of BEVIRI in a case of a recurrent relapsing low-grade glioma of the pineal region, subjected to multiple neurosurgical interventions, also treated with a carboplatin-etoposide regimen and a radiation course, at present at one-year follow-up showing a stable response, with no adverse events. Frontiers Media S.A. 2023-09-20 /pmc/articles/PMC10547897/ /pubmed/37799478 http://dx.doi.org/10.3389/fonc.2023.1244628 Text en Copyright © 2023 Castelli, Fonte, Guidi, Tellini, Di Nicola, Iacono, Buccoliero, Greto, Genitori and Sardi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Castelli, Barbara Fonte, Carla Guidi, Milena Tellini, Marco Di Nicola, Marco Iacono, Alessandro Buccoliero, Anna Maria Greto, Daniela Genitori, Lorenzo Sardi, Iacopo Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
title | Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
title_full | Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
title_fullStr | Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
title_full_unstemmed | Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
title_short | Bevacizumab-Irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
title_sort | bevacizumab-irinotecan combination therapy in recurrent low-grade glioma, previously treated with chemo-radiotherapy: a case report |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547897/ https://www.ncbi.nlm.nih.gov/pubmed/37799478 http://dx.doi.org/10.3389/fonc.2023.1244628 |
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