JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

Monocytes are key effectors in autoimmunity-related diseases in the central nervous system (CNS) due to the critical roles of these cells in the production of proinflammatory cytokines, differentiation of T-helper (Th) cells, and antigen presentation. The JAK–STAT signaling is crucial for initiating...

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Detalles Bibliográficos
Autores principales: Shao, Shuai, Chen, Chengjuan, Shi, Gaona, Zhou, Yu, Wei, Yazi, Wu, Lei, Sun, Lan, Zhang, Tiantai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547959/
https://www.ncbi.nlm.nih.gov/pubmed/37799385
http://dx.doi.org/10.1016/j.apsb.2023.07.026

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