Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans lead to neurolipofuscinosis (NCL) and is important in removi...

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Detalles Bibliográficos
Autores principales: Ouyang, Xiaosen, Wani, Willayat Y., Benavides, Gloria A., Redmann, Matthew J., Vo, Hai, van Groen, Thomas, Darley-Usmar, Victor M., Zhang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547960/
https://www.ncbi.nlm.nih.gov/pubmed/37799377
http://dx.doi.org/10.1016/j.apsb.2023.07.015

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