MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis

The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been recently identified as a neurotrophic factor, but its role in hepatic fibrosis is unknown. Here, we found that MANF was upregulated in the fibrotic liver tissues of the patients with chronic liver diseases and of mice treated wi...

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Detalles Bibliográficos
Autores principales: Hou, Chao, Wang, Dong, Zhao, Mingxia, Ballar, Petek, Zhang, Xinru, Mei, Qiong, Wang, Wei, Li, Xiang, Sheng, Qiang, Liu, Jun, Wei, Chuansheng, Shen, Yujun, Yang, Yi, Wang, Peng, Shao, Juntang, Xu, Sa, Wang, Fuyan, Sun, Yang, Shen, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547964/
https://www.ncbi.nlm.nih.gov/pubmed/37799387
http://dx.doi.org/10.1016/j.apsb.2023.07.027

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