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A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer

It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed light on another attractive strategy for PDAC...

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Detalles Bibliográficos
Autores principales:	Liu, Yang, Zhang, Xiaowei, Zhang, Ping, He, Tingting, Zhang, Weitao, Ma, Dingyuan, Li, Ping, Chen, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548051/ https://www.ncbi.nlm.nih.gov/pubmed/37799380 http://dx.doi.org/10.1016/j.apsb.2023.07.018

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