Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness

Although ion transporters and channels have been extensively studied over the last couple of decades, there are still unresolved aspects with regards to their contribution to cancer cell biology. Recent work by Folcher et al (2023) reports a critical role for Na(+) leak channel NALCN in metastatic p...

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Detalles Bibliográficos
Autores principales: Stejerean‐Todoran, Ioana, Bogeski, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548164/
https://www.ncbi.nlm.nih.gov/pubmed/37635635
http://dx.doi.org/10.15252/embj.2023114986
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author Stejerean‐Todoran, Ioana
Bogeski, Ivan
author_facet Stejerean‐Todoran, Ioana
Bogeski, Ivan
author_sort Stejerean‐Todoran, Ioana
collection PubMed
description Although ion transporters and channels have been extensively studied over the last couple of decades, there are still unresolved aspects with regards to their contribution to cancer cell biology. Recent work by Folcher et al (2023) reports a critical role for Na(+) leak channel NALCN in metastatic prostate cancer. The study demonstrates that NALCN promotes metastatic spread to distant organs by controlling Ca(2+) signaling.
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spelling pubmed-105481642023-10-05 Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness Stejerean‐Todoran, Ioana Bogeski, Ivan EMBO J News & Views Although ion transporters and channels have been extensively studied over the last couple of decades, there are still unresolved aspects with regards to their contribution to cancer cell biology. Recent work by Folcher et al (2023) reports a critical role for Na(+) leak channel NALCN in metastatic prostate cancer. The study demonstrates that NALCN promotes metastatic spread to distant organs by controlling Ca(2+) signaling. John Wiley and Sons Inc. 2023-08-28 /pmc/articles/PMC10548164/ /pubmed/37635635 http://dx.doi.org/10.15252/embj.2023114986 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Stejerean‐Todoran, Ioana
Bogeski, Ivan
Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
title Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
title_full Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
title_fullStr Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
title_full_unstemmed Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
title_short Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
title_sort malignant currents: sodium leak channel nalcn propels prostate cancer aggressiveness
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548164/
https://www.ncbi.nlm.nih.gov/pubmed/37635635
http://dx.doi.org/10.15252/embj.2023114986
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