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Efficient shRNA-based knockdown of multiple target genes for cell therapy using a chimeric miRNA cluster platform

Genome engineering technologies are powerful tools in cell-based immunotherapy to optimize or fine-tune cell functionalities. However, their use for multiple gene edits poses relevant biological and technical challenges. Short hairpin RNA (shRNA)-based cell engineering bypasses these criticalities a...

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Detalles Bibliográficos
Autores principales:	Rossi, Matteo, Steklov, Mikhail, Huberty, Fanny, Nguyen, Thuy, Marijsse, Jérôme, Jacques-Hespel, Céline, Najm, Paul, Lonez, Caroline, Breman, Eytan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548280/ https://www.ncbi.nlm.nih.gov/pubmed/37799328 http://dx.doi.org/10.1016/j.omtn.2023.102038

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