Magainin 2-derived stapled peptides derived with the ability to deliver pDNA, mRNA, and siRNA into cells

We have developed cell-penetrating stapled peptides based on the amphipathic antimicrobial peptide magainin 2 for intracellular delivery of nucleic acids such as pDNA, mRNA, and siRNA. Various types of stapled peptides with a cross-linked structure were synthesised in the hydrophobic region of the a...

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Detalles Bibliográficos
Autores principales: Hirano, Motoharu, Yokoo, Hidetomo, Goto, Chihiro, Oba, Makoto, Misawa, Takashi, Demizu, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548513/
https://www.ncbi.nlm.nih.gov/pubmed/37799999
http://dx.doi.org/10.1039/d3sc04124g

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