Cargando…

Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio

Rabies is an important public health concern in North America because of recent epidemics of a rabies virus variant associated with raccoons. The costs associated with surveillance, diagnostic testing, and post-exposure treatment of humans exposed to rabies have fostered coordinated efforts to contr...

Descripción completa

Detalles Bibliográficos
Autores principales: Russell, Colin A, Smith, David L, Childs, James E, Real, Leslie A
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1054883/
https://www.ncbi.nlm.nih.gov/pubmed/15737065
http://dx.doi.org/10.1371/journal.pbio.0030088
_version_ 1782123271707164672
author Russell, Colin A
Smith, David L
Childs, James E
Real, Leslie A
author_facet Russell, Colin A
Smith, David L
Childs, James E
Real, Leslie A
author_sort Russell, Colin A
collection PubMed
description Rabies is an important public health concern in North America because of recent epidemics of a rabies virus variant associated with raccoons. The costs associated with surveillance, diagnostic testing, and post-exposure treatment of humans exposed to rabies have fostered coordinated efforts to control rabies spread by distributing an oral rabies vaccine to wild raccoons. Authorities have tried to contain westward expansion of the epidemic front of raccoon-associated rabies via a vaccine corridor established in counties of eastern Ohio, western Pennsylvania, and West Virginia. Although sporadic cases of rabies have been identified in Ohio since oral rabies vaccine distribution in 1998, the first evidence of a significant breach in this vaccine corridor was not detected until 2004 in Lake County, Ohio. Herein, we forecast the spatial spread of rabies in Ohio from this breach using a stochastic spatial model that was first developed for exploratory data analysis in Connecticut and next used to successfully hind-cast wave-front dynamics of rabies spread across New York. The projections, based on expansion from the Lake County breach, are strongly affected by the spread of rabies by rare, but unpredictable long-distance translocation of rabid raccoons; rabies may traverse central Ohio at a rate 2.5-fold greater than previously analyzed wildlife epidemics. Using prior estimates of the impact of local heterogeneities on wave-front propagation and of the time lag between surveillance-based detection of an initial rabies case to full-blown epidemic, specific regions within the state are identified for vaccine delivery and expanded surveillance effort.
format Text
id pubmed-1054883
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-10548832005-03-01 Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio Russell, Colin A Smith, David L Childs, James E Real, Leslie A PLoS Biol Research Article Rabies is an important public health concern in North America because of recent epidemics of a rabies virus variant associated with raccoons. The costs associated with surveillance, diagnostic testing, and post-exposure treatment of humans exposed to rabies have fostered coordinated efforts to control rabies spread by distributing an oral rabies vaccine to wild raccoons. Authorities have tried to contain westward expansion of the epidemic front of raccoon-associated rabies via a vaccine corridor established in counties of eastern Ohio, western Pennsylvania, and West Virginia. Although sporadic cases of rabies have been identified in Ohio since oral rabies vaccine distribution in 1998, the first evidence of a significant breach in this vaccine corridor was not detected until 2004 in Lake County, Ohio. Herein, we forecast the spatial spread of rabies in Ohio from this breach using a stochastic spatial model that was first developed for exploratory data analysis in Connecticut and next used to successfully hind-cast wave-front dynamics of rabies spread across New York. The projections, based on expansion from the Lake County breach, are strongly affected by the spread of rabies by rare, but unpredictable long-distance translocation of rabid raccoons; rabies may traverse central Ohio at a rate 2.5-fold greater than previously analyzed wildlife epidemics. Using prior estimates of the impact of local heterogeneities on wave-front propagation and of the time lag between surveillance-based detection of an initial rabies case to full-blown epidemic, specific regions within the state are identified for vaccine delivery and expanded surveillance effort. Public Library of Science 2005-03 2005-03-01 /pmc/articles/PMC1054883/ /pubmed/15737065 http://dx.doi.org/10.1371/journal.pbio.0030088 Text en Copyright: © 2005 Real et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Russell, Colin A
Smith, David L
Childs, James E
Real, Leslie A
Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio
title Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio
title_full Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio
title_fullStr Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio
title_full_unstemmed Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio
title_short Predictive Spatial Dynamics and Strategic Planning for Raccoon Rabies Emergence in Ohio
title_sort predictive spatial dynamics and strategic planning for raccoon rabies emergence in ohio
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1054883/
https://www.ncbi.nlm.nih.gov/pubmed/15737065
http://dx.doi.org/10.1371/journal.pbio.0030088
work_keys_str_mv AT russellcolina predictivespatialdynamicsandstrategicplanningforraccoonrabiesemergenceinohio
AT smithdavidl predictivespatialdynamicsandstrategicplanningforraccoonrabiesemergenceinohio
AT childsjamese predictivespatialdynamicsandstrategicplanningforraccoonrabiesemergenceinohio
AT reallesliea predictivespatialdynamicsandstrategicplanningforraccoonrabiesemergenceinohio