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Small molecule inducers of actinobacteria natural product biosynthesis

 : Actinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regu...

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Detalles Bibliográficos
Autores principales: Alwali, Amir Y, Parkinson, Elizabeth I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549211/
https://www.ncbi.nlm.nih.gov/pubmed/37587009
http://dx.doi.org/10.1093/jimb/kuad019
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author Alwali, Amir Y
Parkinson, Elizabeth I
author_facet Alwali, Amir Y
Parkinson, Elizabeth I
author_sort Alwali, Amir Y
collection PubMed
description  : Actinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products (NPs) being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can increase titers of known NPs as well as enabling discovery of novel NPs typically produced at undetectable levels. These elicitors can be NPs, including antibiotics or hormones, or synthetic compounds. In recent years, there has been a growing interest in the use of small molecule elicitors to induce the production of secondary metabolites from actinobacteria, especially for the discovery of NPs from “silent” biosynthetic gene clusters. This review aims to highlight classes of molecules that induce secondary metabolite production in actinobacteria and to describe the potential mechanisms of induction. ONE-SENTENCE SUMMARY: This review describes chemical elicitors of actinobacteria natural products described to date and the proposed mechanisms of induction.
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spelling pubmed-105492112023-10-05 Small molecule inducers of actinobacteria natural product biosynthesis Alwali, Amir Y Parkinson, Elizabeth I J Ind Microbiol Biotechnol Natural Products  : Actinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products (NPs) being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can increase titers of known NPs as well as enabling discovery of novel NPs typically produced at undetectable levels. These elicitors can be NPs, including antibiotics or hormones, or synthetic compounds. In recent years, there has been a growing interest in the use of small molecule elicitors to induce the production of secondary metabolites from actinobacteria, especially for the discovery of NPs from “silent” biosynthetic gene clusters. This review aims to highlight classes of molecules that induce secondary metabolite production in actinobacteria and to describe the potential mechanisms of induction. ONE-SENTENCE SUMMARY: This review describes chemical elicitors of actinobacteria natural products described to date and the proposed mechanisms of induction. Oxford University Press 2023-08-16 /pmc/articles/PMC10549211/ /pubmed/37587009 http://dx.doi.org/10.1093/jimb/kuad019 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Society of Industrial Microbiology and Biotechnology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Natural Products
Alwali, Amir Y
Parkinson, Elizabeth I
Small molecule inducers of actinobacteria natural product biosynthesis
title Small molecule inducers of actinobacteria natural product biosynthesis
title_full Small molecule inducers of actinobacteria natural product biosynthesis
title_fullStr Small molecule inducers of actinobacteria natural product biosynthesis
title_full_unstemmed Small molecule inducers of actinobacteria natural product biosynthesis
title_short Small molecule inducers of actinobacteria natural product biosynthesis
title_sort small molecule inducers of actinobacteria natural product biosynthesis
topic Natural Products
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549211/
https://www.ncbi.nlm.nih.gov/pubmed/37587009
http://dx.doi.org/10.1093/jimb/kuad019
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