Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report

The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Pr...

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Autores principales: Wilson, Lindsay, Chang, Ju-Wei, Meier, Stuart, Ganief, Tariq, Ganief, Naadir, Oelofse, Suzette, Baillie, Vicky, Nunes, Marta C, Madhi, Shabir A, Blackburn, Jonathan, Dheda, Keertan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549212/
https://www.ncbi.nlm.nih.gov/pubmed/37799131
http://dx.doi.org/10.1093/ofid/ofad451
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author Wilson, Lindsay
Chang, Ju-Wei
Meier, Stuart
Ganief, Tariq
Ganief, Naadir
Oelofse, Suzette
Baillie, Vicky
Nunes, Marta C
Madhi, Shabir A
Blackburn, Jonathan
Dheda, Keertan
author_facet Wilson, Lindsay
Chang, Ju-Wei
Meier, Stuart
Ganief, Tariq
Ganief, Naadir
Oelofse, Suzette
Baillie, Vicky
Nunes, Marta C
Madhi, Shabir A
Blackburn, Jonathan
Dheda, Keertan
author_sort Wilson, Lindsay
collection PubMed
description The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Protein-specific machine learning analysis outlined biomarker combinations able to differentiate COVID-19 pneumonia from non-COVID-19 pneumonia controls.
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spelling pubmed-105492122023-10-05 Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report Wilson, Lindsay Chang, Ju-Wei Meier, Stuart Ganief, Tariq Ganief, Naadir Oelofse, Suzette Baillie, Vicky Nunes, Marta C Madhi, Shabir A Blackburn, Jonathan Dheda, Keertan Open Forum Infect Dis Brief Report The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Protein-specific machine learning analysis outlined biomarker combinations able to differentiate COVID-19 pneumonia from non-COVID-19 pneumonia controls. Oxford University Press 2023-08-31 /pmc/articles/PMC10549212/ /pubmed/37799131 http://dx.doi.org/10.1093/ofid/ofad451 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Wilson, Lindsay
Chang, Ju-Wei
Meier, Stuart
Ganief, Tariq
Ganief, Naadir
Oelofse, Suzette
Baillie, Vicky
Nunes, Marta C
Madhi, Shabir A
Blackburn, Jonathan
Dheda, Keertan
Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report
title Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report
title_full Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report
title_fullStr Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report
title_full_unstemmed Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report
title_short Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report
title_sort proteomic profiling of urine from hospitalized patients with severe pneumonia due to sars-cov-2 vs other causes: a preliminary report
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549212/
https://www.ncbi.nlm.nih.gov/pubmed/37799131
http://dx.doi.org/10.1093/ofid/ofad451
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