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Antitumour imidazotetrazines: past, present… and future?

It is 40 years since the publication of the patent that announced the imidazotetrazines temozolomide and mitozolomide to the world and 30 since the discovery that they function as prodrugs of alkyldiazonium reactive intermediates. Temozolomide combined with radiation is established as the first-line...

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Detalles Bibliográficos
Autores principales: Stevens, Malcolm F. G., Wheelhouse, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549241/
https://www.ncbi.nlm.nih.gov/pubmed/37799580
http://dx.doi.org/10.1039/d3cb00076a