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Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection
Hemophagocytic lymphohistiocytosis is usually considered a rapidly progressive fatal illness with poor outcomes. It is of two types: primary or familial and secondary. In patients with HIV, opportunistic infections are the secondary triggers of HLH. First line of management of infection associated H...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549904/ https://www.ncbi.nlm.nih.gov/pubmed/37800079 http://dx.doi.org/10.4103/jgid.jgid_190_22 |
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author | Divyashree, Krishna Singh, Harpreet Parkhi, Mayur Karmakar, Indrani Sachdeva, Man Updesh Singh Suri, Vikas Bhalla, Ashish |
author_facet | Divyashree, Krishna Singh, Harpreet Parkhi, Mayur Karmakar, Indrani Sachdeva, Man Updesh Singh Suri, Vikas Bhalla, Ashish |
author_sort | Divyashree, Krishna |
collection | PubMed |
description | Hemophagocytic lymphohistiocytosis is usually considered a rapidly progressive fatal illness with poor outcomes. It is of two types: primary or familial and secondary. In patients with HIV, opportunistic infections are the secondary triggers of HLH. First line of management of infection associated HLH is treatment of the underlying infection. Here, we present a case of HLH in HIV infection due to disseminated histoplasmosis managed with liposomal amphotericin B, who required immunosuppressive therapy with intravenous immunoglobulin and dexamethasone due to nonresponse to primary therapy. |
format | Online Article Text |
id | pubmed-10549904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-105499042023-10-05 Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection Divyashree, Krishna Singh, Harpreet Parkhi, Mayur Karmakar, Indrani Sachdeva, Man Updesh Singh Suri, Vikas Bhalla, Ashish J Glob Infect Dis Case Report Hemophagocytic lymphohistiocytosis is usually considered a rapidly progressive fatal illness with poor outcomes. It is of two types: primary or familial and secondary. In patients with HIV, opportunistic infections are the secondary triggers of HLH. First line of management of infection associated HLH is treatment of the underlying infection. Here, we present a case of HLH in HIV infection due to disseminated histoplasmosis managed with liposomal amphotericin B, who required immunosuppressive therapy with intravenous immunoglobulin and dexamethasone due to nonresponse to primary therapy. Wolters Kluwer - Medknow 2023-08-11 /pmc/articles/PMC10549904/ /pubmed/37800079 http://dx.doi.org/10.4103/jgid.jgid_190_22 Text en Copyright: © 2023 Journal of Global Infectious Diseases https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Divyashree, Krishna Singh, Harpreet Parkhi, Mayur Karmakar, Indrani Sachdeva, Man Updesh Singh Suri, Vikas Bhalla, Ashish Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection |
title | Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection |
title_full | Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection |
title_fullStr | Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection |
title_full_unstemmed | Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection |
title_short | Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection |
title_sort | hemophagocytic lymphohistiocytosis due to disseminated histoplasmosis in a patient with hiv infection |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549904/ https://www.ncbi.nlm.nih.gov/pubmed/37800079 http://dx.doi.org/10.4103/jgid.jgid_190_22 |
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