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Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study

This study aimed to determine whether blood neurofilament light chain (NfL) modifies the association of olfactory dysfunction (OD) with long‐term cognitive decline. A total of 1125 non‐demented older adults in the Shanghai Aging Study were evaluated for baseline olfaction (12‐item Sniffin’ Sticks Sm...

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Autores principales: Xiao, Zhenxu, Wu, Wanqing, Ma, Xiaoxi, Wu, Jie, Liang, Xiaoniu, Cao, Yang, Zhao, Qianhua, Ding, Ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549963/
https://www.ncbi.nlm.nih.gov/pubmed/37800096
http://dx.doi.org/10.1002/dad2.12485
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author Xiao, Zhenxu
Wu, Wanqing
Ma, Xiaoxi
Wu, Jie
Liang, Xiaoniu
Cao, Yang
Zhao, Qianhua
Ding, Ding
author_facet Xiao, Zhenxu
Wu, Wanqing
Ma, Xiaoxi
Wu, Jie
Liang, Xiaoniu
Cao, Yang
Zhao, Qianhua
Ding, Ding
author_sort Xiao, Zhenxu
collection PubMed
description This study aimed to determine whether blood neurofilament light chain (NfL) modifies the association of olfactory dysfunction (OD) with long‐term cognitive decline. A total of 1125 non‐demented older adults in the Shanghai Aging Study were evaluated for baseline olfaction (12‐item Sniffin’ Sticks Smell Test) and cognitive trajectory by a 12‐year follow‐up. Baseline blood NfL was quantified using Single Molecular Array assay, and dichotomized into low and high levels based on the median value of concentration. The Mini‐Mental State Examination (MMSE) and Telephone Interview for Cognitive Status‐40 were used to assess participants’ cognitive function. Cognitive decline was ascertained when dementia was diagnosed or documented in the medical record during follow‐up, or the MMSE declining rate (slope) was 1.0 SD larger than the group mean. OD participants presented a steeper trajectory of MMSE score (p interaction = 0.004) and a high risk of cognitive decline (adjusted HR [95% CI], 1.82 [1.11, 2.98]) only in those with high NfL. Participants with combined OD and high NfL showed the highest risk of cognitive decline (adjusted HR, 2.43 [1.20, 4.92]). OD, especially in combination with high blood NfL concentration, may be able to identify individuals who later incur cognitive deterioration.
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spelling pubmed-105499632023-10-05 Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study Xiao, Zhenxu Wu, Wanqing Ma, Xiaoxi Wu, Jie Liang, Xiaoniu Cao, Yang Zhao, Qianhua Ding, Ding Alzheimers Dement (Amst) Research Articles This study aimed to determine whether blood neurofilament light chain (NfL) modifies the association of olfactory dysfunction (OD) with long‐term cognitive decline. A total of 1125 non‐demented older adults in the Shanghai Aging Study were evaluated for baseline olfaction (12‐item Sniffin’ Sticks Smell Test) and cognitive trajectory by a 12‐year follow‐up. Baseline blood NfL was quantified using Single Molecular Array assay, and dichotomized into low and high levels based on the median value of concentration. The Mini‐Mental State Examination (MMSE) and Telephone Interview for Cognitive Status‐40 were used to assess participants’ cognitive function. Cognitive decline was ascertained when dementia was diagnosed or documented in the medical record during follow‐up, or the MMSE declining rate (slope) was 1.0 SD larger than the group mean. OD participants presented a steeper trajectory of MMSE score (p interaction = 0.004) and a high risk of cognitive decline (adjusted HR [95% CI], 1.82 [1.11, 2.98]) only in those with high NfL. Participants with combined OD and high NfL showed the highest risk of cognitive decline (adjusted HR, 2.43 [1.20, 4.92]). OD, especially in combination with high blood NfL concentration, may be able to identify individuals who later incur cognitive deterioration. John Wiley and Sons Inc. 2023-10-04 /pmc/articles/PMC10549963/ /pubmed/37800096 http://dx.doi.org/10.1002/dad2.12485 Text en © 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Xiao, Zhenxu
Wu, Wanqing
Ma, Xiaoxi
Wu, Jie
Liang, Xiaoniu
Cao, Yang
Zhao, Qianhua
Ding, Ding
Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study
title Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study
title_full Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study
title_fullStr Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study
title_full_unstemmed Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study
title_short Olfactory function, neurofilament light chain, and cognitive trajectory: A 12‐year follow‐up of the Shanghai Aging Study
title_sort olfactory function, neurofilament light chain, and cognitive trajectory: a 12‐year follow‐up of the shanghai aging study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549963/
https://www.ncbi.nlm.nih.gov/pubmed/37800096
http://dx.doi.org/10.1002/dad2.12485
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