Cargando…

Redefining the polypill: pros and cons in cardiovascular precision medicine

Polypill is a multi-drug formulation in a single pill intended to simplify the drug regimen and reduce medication-induced adverse effects. The most common multidrug combinations in a polypill are used to treat cardiovascular diseases and are targeted against key modifiable risk factors such as hyper...

Descripción completa

Detalles Bibliográficos
Autores principales: Birla, Siddharth, Angural, Arshia, Madathumchalil, Arya, Shende, Ritika V., Shastry, Sharvani V., Mahadevappa, Manjappa, Shambhu, Sunil Kumar, Vishwanath, Prashant, Prashant, Akila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549989/
https://www.ncbi.nlm.nih.gov/pubmed/37799963
http://dx.doi.org/10.3389/fphar.2023.1268119
_version_ 1785115437631012864
author Birla, Siddharth
Angural, Arshia
Madathumchalil, Arya
Shende, Ritika V.
Shastry, Sharvani V.
Mahadevappa, Manjappa
Shambhu, Sunil Kumar
Vishwanath, Prashant
Prashant, Akila
author_facet Birla, Siddharth
Angural, Arshia
Madathumchalil, Arya
Shende, Ritika V.
Shastry, Sharvani V.
Mahadevappa, Manjappa
Shambhu, Sunil Kumar
Vishwanath, Prashant
Prashant, Akila
author_sort Birla, Siddharth
collection PubMed
description Polypill is a multi-drug formulation in a single pill intended to simplify the drug regimen and reduce medication-induced adverse effects. The most common multidrug combinations in a polypill are used to treat cardiovascular diseases and are targeted against key modifiable risk factors such as hypertension and hyperlipidemia. These contain blood-pressure lowering agents, statins, and anti-platelet agents usually in a fixed dose. Polypills can be an affordable therapeutic intervention for treating high-risk patients, as these are proven to increase patients’ adherence to medication and improve clinical outcomes. Over the previous years, randomized clinical trials of several polypills have yielded contradictory findings, raising skepticism regarding their widespread use in primary disease prevention. Here, we have reviewed the concept of polypills, the evidence-based strengths, the limitations of this polypharmacy intervention strategy, and discussed future directions for their use in the primary and secondary preventive management of cardiovascular diseases and associated risk factors.
format Online
Article
Text
id pubmed-10549989
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105499892023-10-05 Redefining the polypill: pros and cons in cardiovascular precision medicine Birla, Siddharth Angural, Arshia Madathumchalil, Arya Shende, Ritika V. Shastry, Sharvani V. Mahadevappa, Manjappa Shambhu, Sunil Kumar Vishwanath, Prashant Prashant, Akila Front Pharmacol Pharmacology Polypill is a multi-drug formulation in a single pill intended to simplify the drug regimen and reduce medication-induced adverse effects. The most common multidrug combinations in a polypill are used to treat cardiovascular diseases and are targeted against key modifiable risk factors such as hypertension and hyperlipidemia. These contain blood-pressure lowering agents, statins, and anti-platelet agents usually in a fixed dose. Polypills can be an affordable therapeutic intervention for treating high-risk patients, as these are proven to increase patients’ adherence to medication and improve clinical outcomes. Over the previous years, randomized clinical trials of several polypills have yielded contradictory findings, raising skepticism regarding their widespread use in primary disease prevention. Here, we have reviewed the concept of polypills, the evidence-based strengths, the limitations of this polypharmacy intervention strategy, and discussed future directions for their use in the primary and secondary preventive management of cardiovascular diseases and associated risk factors. Frontiers Media S.A. 2023-09-19 /pmc/articles/PMC10549989/ /pubmed/37799963 http://dx.doi.org/10.3389/fphar.2023.1268119 Text en Copyright © 2023 Birla, Angural, Madathumchalil, Shende, Shastry, Mahadevappa, Shambhu, Vishwanath and Prashant. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Birla, Siddharth
Angural, Arshia
Madathumchalil, Arya
Shende, Ritika V.
Shastry, Sharvani V.
Mahadevappa, Manjappa
Shambhu, Sunil Kumar
Vishwanath, Prashant
Prashant, Akila
Redefining the polypill: pros and cons in cardiovascular precision medicine
title Redefining the polypill: pros and cons in cardiovascular precision medicine
title_full Redefining the polypill: pros and cons in cardiovascular precision medicine
title_fullStr Redefining the polypill: pros and cons in cardiovascular precision medicine
title_full_unstemmed Redefining the polypill: pros and cons in cardiovascular precision medicine
title_short Redefining the polypill: pros and cons in cardiovascular precision medicine
title_sort redefining the polypill: pros and cons in cardiovascular precision medicine
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549989/
https://www.ncbi.nlm.nih.gov/pubmed/37799963
http://dx.doi.org/10.3389/fphar.2023.1268119
work_keys_str_mv AT birlasiddharth redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT anguralarshia redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT madathumchalilarya redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT shenderitikav redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT shastrysharvaniv redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT mahadevappamanjappa redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT shambhusunilkumar redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT vishwanathprashant redefiningthepolypillprosandconsincardiovascularprecisionmedicine
AT prashantakila redefiningthepolypillprosandconsincardiovascularprecisionmedicine