Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery

The urea cycle is a metabolic pathway that excretes nitrogenous waste products from the body. Urea cycle disorders (UCDs) result from enzymatic deficiencies within this pathway, which can lead to life-threatening hyperammonemia. Gastric bypass-related hyperammonemia in patients who have undergone Ro...

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Autores principales: Loeffler, Jeffrey, Elfiky, Ahmed, Al Moussawi, Hassan, Ravindran, Nishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550022/
https://www.ncbi.nlm.nih.gov/pubmed/37799484
http://dx.doi.org/10.14309/crj.0000000000001164
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author Loeffler, Jeffrey
Elfiky, Ahmed
Al Moussawi, Hassan
Ravindran, Nishal
author_facet Loeffler, Jeffrey
Elfiky, Ahmed
Al Moussawi, Hassan
Ravindran, Nishal
author_sort Loeffler, Jeffrey
collection PubMed
description The urea cycle is a metabolic pathway that excretes nitrogenous waste products from the body. Urea cycle disorders (UCDs) result from enzymatic deficiencies within this pathway, which can lead to life-threatening hyperammonemia. Gastric bypass-related hyperammonemia in patients who have undergone Roux-en-Y gastric bypass surgery has been previously reported. UCDs have been implicated as a cause of gastric bypass-related hyperammonemia. In this report, we present the case of a patient with a history of bariatric surgery who experienced severe hyperammonemia encephalopathy triggered by a gastrointestinal bleed due to an undiagnosed UCD.
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spelling pubmed-105500222023-10-05 Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery Loeffler, Jeffrey Elfiky, Ahmed Al Moussawi, Hassan Ravindran, Nishal ACG Case Rep J Case Report The urea cycle is a metabolic pathway that excretes nitrogenous waste products from the body. Urea cycle disorders (UCDs) result from enzymatic deficiencies within this pathway, which can lead to life-threatening hyperammonemia. Gastric bypass-related hyperammonemia in patients who have undergone Roux-en-Y gastric bypass surgery has been previously reported. UCDs have been implicated as a cause of gastric bypass-related hyperammonemia. In this report, we present the case of a patient with a history of bariatric surgery who experienced severe hyperammonemia encephalopathy triggered by a gastrointestinal bleed due to an undiagnosed UCD. Wolters Kluwer 2023-10-03 /pmc/articles/PMC10550022/ /pubmed/37799484 http://dx.doi.org/10.14309/crj.0000000000001164 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Loeffler, Jeffrey
Elfiky, Ahmed
Al Moussawi, Hassan
Ravindran, Nishal
Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery
title Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery
title_full Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery
title_fullStr Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery
title_full_unstemmed Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery
title_short Hyperammonemia Encephalopathy due to Urea Cycle Disorder Precipitated by Gastrointestinal Bleed in the Setting of Prior Bariatric Surgery
title_sort hyperammonemia encephalopathy due to urea cycle disorder precipitated by gastrointestinal bleed in the setting of prior bariatric surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550022/
https://www.ncbi.nlm.nih.gov/pubmed/37799484
http://dx.doi.org/10.14309/crj.0000000000001164
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