Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease

INTRODUCTION: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals. METHODS: In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines. RES...

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Detalles Bibliográficos
Autores principales: de Brito, Maíra Sant Anna Genaro, de Marchi, Micheli Said, Perin, Matheus Yung, Côsso, Isabelle da Silva, Bumlai, Renan Urt Mansur, da Silva, Waldemar Vaz, Prado, Adriana Yuki Mello, da Cruz, Thais Campos Dias, Avila, Eudes Thiago Pereira, Damazo, Amílcar Sabino, Slhessarenko, Renata Dezengrini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550088/
https://www.ncbi.nlm.nih.gov/pubmed/37792834
http://dx.doi.org/10.1590/0037-8682-0278-2023
Descripción
Sumario:INTRODUCTION: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals. METHODS: In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines. RESULTS: All participants were female and had pain in 12 joints on average, with 41.17% exhibiting moderate disease activity. Histopathological analysis revealed collagen deposition. Indirect immunofluorescence detected the CHIKV glycoprotein E1 antigen, and an increase in cytokines. CONCLUSIONS: Persistent inflammation and ineffective antiviral immune responses leading to antigen persistence may contribute to chronic CHIKV arthritis.

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