Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease

INTRODUCTION: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals. METHODS: In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines. RES...

Descripción completa

Detalles Bibliográficos
Autores principales: de Brito, Maíra Sant Anna Genaro, de Marchi, Micheli Said, Perin, Matheus Yung, Côsso, Isabelle da Silva, Bumlai, Renan Urt Mansur, da Silva, Waldemar Vaz, Prado, Adriana Yuki Mello, da Cruz, Thais Campos Dias, Avila, Eudes Thiago Pereira, Damazo, Amílcar Sabino, Slhessarenko, Renata Dezengrini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550088/
https://www.ncbi.nlm.nih.gov/pubmed/37792834
http://dx.doi.org/10.1590/0037-8682-0278-2023
_version_ 1785115457685028864
author de Brito, Maíra Sant Anna Genaro
de Marchi, Micheli Said
Perin, Matheus Yung
Côsso, Isabelle da Silva
Bumlai, Renan Urt Mansur
da Silva, Waldemar Vaz
Prado, Adriana Yuki Mello
da Cruz, Thais Campos Dias
Avila, Eudes Thiago Pereira
Damazo, Amílcar Sabino
Slhessarenko, Renata Dezengrini
author_facet de Brito, Maíra Sant Anna Genaro
de Marchi, Micheli Said
Perin, Matheus Yung
Côsso, Isabelle da Silva
Bumlai, Renan Urt Mansur
da Silva, Waldemar Vaz
Prado, Adriana Yuki Mello
da Cruz, Thais Campos Dias
Avila, Eudes Thiago Pereira
Damazo, Amílcar Sabino
Slhessarenko, Renata Dezengrini
author_sort de Brito, Maíra Sant Anna Genaro
collection PubMed
description INTRODUCTION: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals. METHODS: In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines. RESULTS: All participants were female and had pain in 12 joints on average, with 41.17% exhibiting moderate disease activity. Histopathological analysis revealed collagen deposition. Indirect immunofluorescence detected the CHIKV glycoprotein E1 antigen, and an increase in cytokines. CONCLUSIONS: Persistent inflammation and ineffective antiviral immune responses leading to antigen persistence may contribute to chronic CHIKV arthritis.
format Online
Article
Text
id pubmed-10550088
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Sociedade Brasileira de Medicina Tropical - SBMT
record_format MEDLINE/PubMed
spelling pubmed-105500882023-10-05 Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease de Brito, Maíra Sant Anna Genaro de Marchi, Micheli Said Perin, Matheus Yung Côsso, Isabelle da Silva Bumlai, Renan Urt Mansur da Silva, Waldemar Vaz Prado, Adriana Yuki Mello da Cruz, Thais Campos Dias Avila, Eudes Thiago Pereira Damazo, Amílcar Sabino Slhessarenko, Renata Dezengrini Rev Soc Bras Med Trop Short Communication INTRODUCTION: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals. METHODS: In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines. RESULTS: All participants were female and had pain in 12 joints on average, with 41.17% exhibiting moderate disease activity. Histopathological analysis revealed collagen deposition. Indirect immunofluorescence detected the CHIKV glycoprotein E1 antigen, and an increase in cytokines. CONCLUSIONS: Persistent inflammation and ineffective antiviral immune responses leading to antigen persistence may contribute to chronic CHIKV arthritis. Sociedade Brasileira de Medicina Tropical - SBMT 2023-09-22 /pmc/articles/PMC10550088/ /pubmed/37792834 http://dx.doi.org/10.1590/0037-8682-0278-2023 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
de Brito, Maíra Sant Anna Genaro
de Marchi, Micheli Said
Perin, Matheus Yung
Côsso, Isabelle da Silva
Bumlai, Renan Urt Mansur
da Silva, Waldemar Vaz
Prado, Adriana Yuki Mello
da Cruz, Thais Campos Dias
Avila, Eudes Thiago Pereira
Damazo, Amílcar Sabino
Slhessarenko, Renata Dezengrini
Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
title Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
title_full Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
title_fullStr Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
title_full_unstemmed Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
title_short Inflammation, fibrosis and E1 glycoprotein persistence in joint tissue of patients with post-Chikungunya chronic articular disease
title_sort inflammation, fibrosis and e1 glycoprotein persistence in joint tissue of patients with post-chikungunya chronic articular disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550088/
https://www.ncbi.nlm.nih.gov/pubmed/37792834
http://dx.doi.org/10.1590/0037-8682-0278-2023
work_keys_str_mv AT debritomairasantannagenaro inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT demarchimichelisaid inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT perinmatheusyung inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT cossoisabelledasilva inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT bumlairenanurtmansur inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT dasilvawaldemarvaz inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT pradoadrianayukimello inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT dacruzthaiscamposdias inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT avilaeudesthiagopereira inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT damazoamilcarsabino inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease
AT slhessarenkorenatadezengrini inflammationfibrosisande1glycoproteinpersistenceinjointtissueofpatientswithpostchikungunyachronicarticulardisease

Ejemplares similares