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History of primary-series and booster vaccination and protection against Omicron reinfection

Laboratory evidence suggests a possibility of immune imprinting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the differences in the incidence of SARS-CoV-2 reinfection in a cohort of persons who had a primary Omicron infection, but different vaccination...

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Autores principales: Chemaitelly, Hiam, Ayoub, Houssein H., Tang, Patrick, Coyle, Peter V., Yassine, Hadi M., Al Thani, Asmaa A., Al-Khatib, Hebah A., Hasan, Mohammad R., Al-Kanaani, Zaina, Al-Kuwari, Einas, Jeremijenko, Andrew, Kaleeckal, Anvar Hassan, Latif, Ali Nizar, Shaik, Riyazuddin Mohammad, Abdul-Rahim, Hanan F., Nasrallah, Gheyath K., Al-Kuwari, Mohamed Ghaith, Butt, Adeel A., Al-Romaihi, Hamad Eid, Al-Thani, Mohamed H., Al-Khal, Abdullatif, Bertollini, Roberto, Abu-Raddad, Laith J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550237/
https://www.ncbi.nlm.nih.gov/pubmed/37792951
http://dx.doi.org/10.1126/sciadv.adh0761
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author Chemaitelly, Hiam
Ayoub, Houssein H.
Tang, Patrick
Coyle, Peter V.
Yassine, Hadi M.
Al Thani, Asmaa A.
Al-Khatib, Hebah A.
Hasan, Mohammad R.
Al-Kanaani, Zaina
Al-Kuwari, Einas
Jeremijenko, Andrew
Kaleeckal, Anvar Hassan
Latif, Ali Nizar
Shaik, Riyazuddin Mohammad
Abdul-Rahim, Hanan F.
Nasrallah, Gheyath K.
Al-Kuwari, Mohamed Ghaith
Butt, Adeel A.
Al-Romaihi, Hamad Eid
Al-Thani, Mohamed H.
Al-Khal, Abdullatif
Bertollini, Roberto
Abu-Raddad, Laith J.
author_facet Chemaitelly, Hiam
Ayoub, Houssein H.
Tang, Patrick
Coyle, Peter V.
Yassine, Hadi M.
Al Thani, Asmaa A.
Al-Khatib, Hebah A.
Hasan, Mohammad R.
Al-Kanaani, Zaina
Al-Kuwari, Einas
Jeremijenko, Andrew
Kaleeckal, Anvar Hassan
Latif, Ali Nizar
Shaik, Riyazuddin Mohammad
Abdul-Rahim, Hanan F.
Nasrallah, Gheyath K.
Al-Kuwari, Mohamed Ghaith
Butt, Adeel A.
Al-Romaihi, Hamad Eid
Al-Thani, Mohamed H.
Al-Khal, Abdullatif
Bertollini, Roberto
Abu-Raddad, Laith J.
author_sort Chemaitelly, Hiam
collection PubMed
description Laboratory evidence suggests a possibility of immune imprinting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the differences in the incidence of SARS-CoV-2 reinfection in a cohort of persons who had a primary Omicron infection, but different vaccination histories using matched, national, retrospective, cohort studies. Adjusted hazard ratio for reinfection incidence, factoring adjustment for differences in testing rate, was 0.43 [95% confidence interval (CI): 0.39 to 0.49] comparing history of two-dose vaccination to no vaccination, 1.47 (95% CI: 1.23 to 1.76) comparing history of three-dose vaccination to two-dose vaccination, and 0.57 (95% CI: 0.48 to 0.68) comparing history of three-dose vaccination to no vaccination. Divergence in cumulative incidence curves increased markedly when the incidence was dominated by BA.4/BA.5 and BA.2.75* Omicron subvariants. The history of primary-series vaccination enhanced immune protection against Omicron reinfection, but history of booster vaccination compromised protection against Omicron reinfection. These findings do not undermine the public health utility of booster vaccination.
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spelling pubmed-105502372023-10-05 History of primary-series and booster vaccination and protection against Omicron reinfection Chemaitelly, Hiam Ayoub, Houssein H. Tang, Patrick Coyle, Peter V. Yassine, Hadi M. Al Thani, Asmaa A. Al-Khatib, Hebah A. Hasan, Mohammad R. Al-Kanaani, Zaina Al-Kuwari, Einas Jeremijenko, Andrew Kaleeckal, Anvar Hassan Latif, Ali Nizar Shaik, Riyazuddin Mohammad Abdul-Rahim, Hanan F. Nasrallah, Gheyath K. Al-Kuwari, Mohamed Ghaith Butt, Adeel A. Al-Romaihi, Hamad Eid Al-Thani, Mohamed H. Al-Khal, Abdullatif Bertollini, Roberto Abu-Raddad, Laith J. Sci Adv Social and Interdisciplinary Sciences Laboratory evidence suggests a possibility of immune imprinting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the differences in the incidence of SARS-CoV-2 reinfection in a cohort of persons who had a primary Omicron infection, but different vaccination histories using matched, national, retrospective, cohort studies. Adjusted hazard ratio for reinfection incidence, factoring adjustment for differences in testing rate, was 0.43 [95% confidence interval (CI): 0.39 to 0.49] comparing history of two-dose vaccination to no vaccination, 1.47 (95% CI: 1.23 to 1.76) comparing history of three-dose vaccination to two-dose vaccination, and 0.57 (95% CI: 0.48 to 0.68) comparing history of three-dose vaccination to no vaccination. Divergence in cumulative incidence curves increased markedly when the incidence was dominated by BA.4/BA.5 and BA.2.75* Omicron subvariants. The history of primary-series vaccination enhanced immune protection against Omicron reinfection, but history of booster vaccination compromised protection against Omicron reinfection. These findings do not undermine the public health utility of booster vaccination. American Association for the Advancement of Science 2023-10-04 /pmc/articles/PMC10550237/ /pubmed/37792951 http://dx.doi.org/10.1126/sciadv.adh0761 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Social and Interdisciplinary Sciences
Chemaitelly, Hiam
Ayoub, Houssein H.
Tang, Patrick
Coyle, Peter V.
Yassine, Hadi M.
Al Thani, Asmaa A.
Al-Khatib, Hebah A.
Hasan, Mohammad R.
Al-Kanaani, Zaina
Al-Kuwari, Einas
Jeremijenko, Andrew
Kaleeckal, Anvar Hassan
Latif, Ali Nizar
Shaik, Riyazuddin Mohammad
Abdul-Rahim, Hanan F.
Nasrallah, Gheyath K.
Al-Kuwari, Mohamed Ghaith
Butt, Adeel A.
Al-Romaihi, Hamad Eid
Al-Thani, Mohamed H.
Al-Khal, Abdullatif
Bertollini, Roberto
Abu-Raddad, Laith J.
History of primary-series and booster vaccination and protection against Omicron reinfection
title History of primary-series and booster vaccination and protection against Omicron reinfection
title_full History of primary-series and booster vaccination and protection against Omicron reinfection
title_fullStr History of primary-series and booster vaccination and protection against Omicron reinfection
title_full_unstemmed History of primary-series and booster vaccination and protection against Omicron reinfection
title_short History of primary-series and booster vaccination and protection against Omicron reinfection
title_sort history of primary-series and booster vaccination and protection against omicron reinfection
topic Social and Interdisciplinary Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550237/
https://www.ncbi.nlm.nih.gov/pubmed/37792951
http://dx.doi.org/10.1126/sciadv.adh0761
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