Biochemical pathways represented by Gene Ontology-Causal Activity Models identify distinct phenotypes resulting from mutations in pathways

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Gene inactivation can affect the process(es) in which that gene acts and causally downstream ones, yielding diverse mutant phenotypes. Identifying the genetic pathways resulting in a given phenotype helps us understand how individual genes interact in a functional network. Computable representations...

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Detalles Bibliográficos
Autores principales: Hill, David P, Drabkin, Harold J, Smith, Cynthia L, Van Auken, Kimberly M, D’Eustachio, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550311/
https://www.ncbi.nlm.nih.gov/pubmed/37579192
http://dx.doi.org/10.1093/genetics/iyad152
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