Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans

In a previous study, Paenarthrobacter nicotinovorans was isolated and screened for antimicrobial activity. Many promising antibiotic candidates are not ultimately used because of toxicity. After screening secondary metabolites for antimicrobial activity, they were screened for cytotoxicity in vitro...

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Detalles Bibliográficos
Autores principales: Kakol, Justyna, Vang, Mainor, Sausen, Drew, Steeno, Tracey, Kolokithas, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550371/
https://www.ncbi.nlm.nih.gov/pubmed/37799203
http://dx.doi.org/10.17912/micropub.biology.000923
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author Kakol, Justyna
Vang, Mainor
Sausen, Drew
Steeno, Tracey
Kolokithas, Angelo
author_facet Kakol, Justyna
Vang, Mainor
Sausen, Drew
Steeno, Tracey
Kolokithas, Angelo
author_sort Kakol, Justyna
collection PubMed
description In a previous study, Paenarthrobacter nicotinovorans was isolated and screened for antimicrobial activity. Many promising antibiotic candidates are not ultimately used because of toxicity. After screening secondary metabolites for antimicrobial activity, they were screened for cytotoxicity in vitro in the human HeLa cell line. The results show that there is no detectable cytotoxicity in HeLa cells.
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spelling pubmed-105503712023-10-05 Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans Kakol, Justyna Vang, Mainor Sausen, Drew Steeno, Tracey Kolokithas, Angelo MicroPubl Biol New Finding In a previous study, Paenarthrobacter nicotinovorans was isolated and screened for antimicrobial activity. Many promising antibiotic candidates are not ultimately used because of toxicity. After screening secondary metabolites for antimicrobial activity, they were screened for cytotoxicity in vitro in the human HeLa cell line. The results show that there is no detectable cytotoxicity in HeLa cells. Caltech Library 2023-09-19 /pmc/articles/PMC10550371/ /pubmed/37799203 http://dx.doi.org/10.17912/micropub.biology.000923 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Kakol, Justyna
Vang, Mainor
Sausen, Drew
Steeno, Tracey
Kolokithas, Angelo
Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans
title Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans
title_full Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans
title_fullStr Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans
title_full_unstemmed Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans
title_short Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans
title_sort toxicity of secondary metabolites of paenarthrobacter nicotinovorans
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550371/
https://www.ncbi.nlm.nih.gov/pubmed/37799203
http://dx.doi.org/10.17912/micropub.biology.000923
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