Cargando…
Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience
BACKGROUND: Malignancy is a significant, life-limiting complication after lung transplantation (LuTx) and the second common long-term cause of death. We aimed to investigate its incidence and effect on the outcome. METHODS: This is a retrospective observational study. Between 1996 and 2022, n = 627...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550624/ https://www.ncbi.nlm.nih.gov/pubmed/37810874 http://dx.doi.org/10.1016/j.heliyon.2023.e20592 |
_version_ | 1785115583577063424 |
---|---|
author | Spetsotaki, Konstantina Koch, Achim Taube, Christian Theegarten, Dirk Kamler, Markus Pizanis, Nikolaus |
author_facet | Spetsotaki, Konstantina Koch, Achim Taube, Christian Theegarten, Dirk Kamler, Markus Pizanis, Nikolaus |
author_sort | Spetsotaki, Konstantina |
collection | PubMed |
description | BACKGROUND: Malignancy is a significant, life-limiting complication after lung transplantation (LuTx) and the second common long-term cause of death. We aimed to investigate its incidence and effect on the outcome. METHODS: This is a retrospective observational study. Between 1996 and 2022, n = 627 lung transplantations (LuTx) were performed in our department. We used our institutional database to identify recipients with malignancies after LuTx and examined the malignancies’ incidence and mortality. RESULTS: N = 59 malignancies occurred in n = 55 (8.8%) LuTx recipients. The post-LTx malignancies incidence was 9.4% (59/627). We report the following rates based on their location: n = 17/55 (28,8% of all recipients diagnosed with malignancies) skin, n = 10/55 (16,95%) gastrointestinal, n = 9/55 (15,3%) respiratory, n = 5/55 (8,48%) lymphatic, n = 13/55 (23,6%) other, n = 5 (8,48%) multiple synchronous. During this study period, a total of n = 328 deaths after LuTx was determined. N = 29 (8,84% of all deaths) were malignancy induced, corresponding to a total malignancy-induced mortality of 4.6% (n = 29/627). The majority of deaths were attributed to GI adenocarcinoma and PTLD. Malignancies’ origin, primary COPD diagnosis, type, and specific age group were significantly survival-related (p-values <0.05). The most affected organ was skin and showed the best prognosis. PTLD had the fastest and pancreatic the latest onset. CONCLUSIONS: This is the first report of its kind in a large cohort of german LuTx recipients. The prevalence ranking of the three commonest malignancy were skin > colorectal > PTLD. Post-LTx malignancy was the second commonest cause of death. Further studies are needed, while post-LuTx malignomas remain a serious impairment of long-term LuTx survival. |
format | Online Article Text |
id | pubmed-10550624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105506242023-10-06 Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience Spetsotaki, Konstantina Koch, Achim Taube, Christian Theegarten, Dirk Kamler, Markus Pizanis, Nikolaus Heliyon Research Article BACKGROUND: Malignancy is a significant, life-limiting complication after lung transplantation (LuTx) and the second common long-term cause of death. We aimed to investigate its incidence and effect on the outcome. METHODS: This is a retrospective observational study. Between 1996 and 2022, n = 627 lung transplantations (LuTx) were performed in our department. We used our institutional database to identify recipients with malignancies after LuTx and examined the malignancies’ incidence and mortality. RESULTS: N = 59 malignancies occurred in n = 55 (8.8%) LuTx recipients. The post-LTx malignancies incidence was 9.4% (59/627). We report the following rates based on their location: n = 17/55 (28,8% of all recipients diagnosed with malignancies) skin, n = 10/55 (16,95%) gastrointestinal, n = 9/55 (15,3%) respiratory, n = 5/55 (8,48%) lymphatic, n = 13/55 (23,6%) other, n = 5 (8,48%) multiple synchronous. During this study period, a total of n = 328 deaths after LuTx was determined. N = 29 (8,84% of all deaths) were malignancy induced, corresponding to a total malignancy-induced mortality of 4.6% (n = 29/627). The majority of deaths were attributed to GI adenocarcinoma and PTLD. Malignancies’ origin, primary COPD diagnosis, type, and specific age group were significantly survival-related (p-values <0.05). The most affected organ was skin and showed the best prognosis. PTLD had the fastest and pancreatic the latest onset. CONCLUSIONS: This is the first report of its kind in a large cohort of german LuTx recipients. The prevalence ranking of the three commonest malignancy were skin > colorectal > PTLD. Post-LTx malignancy was the second commonest cause of death. Further studies are needed, while post-LuTx malignomas remain a serious impairment of long-term LuTx survival. Elsevier 2023-09-30 /pmc/articles/PMC10550624/ /pubmed/37810874 http://dx.doi.org/10.1016/j.heliyon.2023.e20592 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Spetsotaki, Konstantina Koch, Achim Taube, Christian Theegarten, Dirk Kamler, Markus Pizanis, Nikolaus Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
title | Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
title_full | Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
title_fullStr | Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
title_full_unstemmed | Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
title_short | Incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
title_sort | incidence of malignancies after lung transplantation and their effect on the outcome. 26 years' experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550624/ https://www.ncbi.nlm.nih.gov/pubmed/37810874 http://dx.doi.org/10.1016/j.heliyon.2023.e20592 |
work_keys_str_mv | AT spetsotakikonstantina incidenceofmalignanciesafterlungtransplantationandtheireffectontheoutcome26yearsexperience AT kochachim incidenceofmalignanciesafterlungtransplantationandtheireffectontheoutcome26yearsexperience AT taubechristian incidenceofmalignanciesafterlungtransplantationandtheireffectontheoutcome26yearsexperience AT theegartendirk incidenceofmalignanciesafterlungtransplantationandtheireffectontheoutcome26yearsexperience AT kamlermarkus incidenceofmalignanciesafterlungtransplantationandtheireffectontheoutcome26yearsexperience AT pizanisnikolaus incidenceofmalignanciesafterlungtransplantationandtheireffectontheoutcome26yearsexperience |