Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression

OBJECTIVES: Metformin is the first line therapy recommended for type 2 diabetes. However, the precise mechanism of action remains unclear and up to a quarter of patients show some degree of intolerance to the drug, with a similar number showing poor response to treatment, limiting its effectiveness....

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Detalles Bibliográficos
Autores principales: Morrice, Nicola, Vainio, Susanne, Mikkola, Kirsi, van Aalten, Lidy, Gallagher, Jennifer R., Ashford, Michael L.J., McNeilly, Alison D., McCrimmon, Rory J., Grosfeld, Alexandra, Serradas, Patricia, Koffert, Jukka, Pearson, Ewan R., Nuutila, Pirjo, Sutherland, Calum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550722/
https://www.ncbi.nlm.nih.gov/pubmed/37717665
http://dx.doi.org/10.1016/j.molmet.2023.101807

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