Cargando…

HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer

Trastuzumab (Tmab) targeted therapy or its combination with chemotherapy is normally insufficient to elicit a comprehensive therapeutic response owing to the inherent or acquired drug resistance and systemic toxicity observed in highly invasive HER2-positive breast cancer. In this study, we propose...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Yuanke, Liu, Jinxing, Zhao, Cong, Sun, Hexing, Huang, Kaiyuan, Xie, Qin, Zeng, De, Lin, Haoyu, Zhou, Benqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550767/
https://www.ncbi.nlm.nih.gov/pubmed/37810752
http://dx.doi.org/10.1016/j.mtbio.2023.100812
_version_ 1785115620967186432
author Liang, Yuanke
Liu, Jinxing
Zhao, Cong
Sun, Hexing
Huang, Kaiyuan
Xie, Qin
Zeng, De
Lin, Haoyu
Zhou, Benqing
author_facet Liang, Yuanke
Liu, Jinxing
Zhao, Cong
Sun, Hexing
Huang, Kaiyuan
Xie, Qin
Zeng, De
Lin, Haoyu
Zhou, Benqing
author_sort Liang, Yuanke
collection PubMed
description Trastuzumab (Tmab) targeted therapy or its combination with chemotherapy is normally insufficient to elicit a comprehensive therapeutic response owing to the inherent or acquired drug resistance and systemic toxicity observed in highly invasive HER2-positive breast cancer. In this study, we propose a novel approach that integrates photothermal therapy (PTT) with targeted therapy and chemotherapy, thereby achieving additive or synergistic therapeutic outcomes. We utilize PEGylated two-dimensional black phosphorus (2D BP) as a nanoplatform and photothermal agent to load chemotherapeutic drug mitoxantrone (MTO) and conjugate with Tmab (BP-PEG-MTO-Tmab). The in vitro and in vivo experiments demonstrated that the HER2-targeting BP-PEG-MTO-Tmab complexes exhibited desirable biocompatibility, safety and enhanced cancer cell uptake efficiency, resulting in increased accumulation and prolonged retention of BP and MTO within tumors. Consequently, the complex improved photothermal and chemotherapy treatment efficacy in HER2-positive cells in vitro and a subcutaneous tumor model in vivo, while minimized harm to normal cells and showed desirable organ compatibility. Collectively, our study provides compelling evidence for the remarkable efficacy of targeted and synergistic chemo-photothermal therapy utilizing all-in-one nanoparticles as a delivery system for BP and chemotherapeutic drug in HER2-positive breast cancer.
format Online
Article
Text
id pubmed-10550767
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105507672023-10-06 HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer Liang, Yuanke Liu, Jinxing Zhao, Cong Sun, Hexing Huang, Kaiyuan Xie, Qin Zeng, De Lin, Haoyu Zhou, Benqing Mater Today Bio Full Length Article Trastuzumab (Tmab) targeted therapy or its combination with chemotherapy is normally insufficient to elicit a comprehensive therapeutic response owing to the inherent or acquired drug resistance and systemic toxicity observed in highly invasive HER2-positive breast cancer. In this study, we propose a novel approach that integrates photothermal therapy (PTT) with targeted therapy and chemotherapy, thereby achieving additive or synergistic therapeutic outcomes. We utilize PEGylated two-dimensional black phosphorus (2D BP) as a nanoplatform and photothermal agent to load chemotherapeutic drug mitoxantrone (MTO) and conjugate with Tmab (BP-PEG-MTO-Tmab). The in vitro and in vivo experiments demonstrated that the HER2-targeting BP-PEG-MTO-Tmab complexes exhibited desirable biocompatibility, safety and enhanced cancer cell uptake efficiency, resulting in increased accumulation and prolonged retention of BP and MTO within tumors. Consequently, the complex improved photothermal and chemotherapy treatment efficacy in HER2-positive cells in vitro and a subcutaneous tumor model in vivo, while minimized harm to normal cells and showed desirable organ compatibility. Collectively, our study provides compelling evidence for the remarkable efficacy of targeted and synergistic chemo-photothermal therapy utilizing all-in-one nanoparticles as a delivery system for BP and chemotherapeutic drug in HER2-positive breast cancer. Elsevier 2023-09-22 /pmc/articles/PMC10550767/ /pubmed/37810752 http://dx.doi.org/10.1016/j.mtbio.2023.100812 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Liang, Yuanke
Liu, Jinxing
Zhao, Cong
Sun, Hexing
Huang, Kaiyuan
Xie, Qin
Zeng, De
Lin, Haoyu
Zhou, Benqing
HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
title HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
title_full HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
title_fullStr HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
title_full_unstemmed HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
title_short HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
title_sort her2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550767/
https://www.ncbi.nlm.nih.gov/pubmed/37810752
http://dx.doi.org/10.1016/j.mtbio.2023.100812
work_keys_str_mv AT liangyuanke her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT liujinxing her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT zhaocong her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT sunhexing her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT huangkaiyuan her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT xieqin her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT zengde her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT linhaoyu her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer
AT zhoubenqing her2targetingtwodimensionalblackphosphorusasananoplatformforchemophotothermaltherapyinbreastcancer